Neuroendocrine Tumors: Personalized Therapy Improves Radiation Delivery for Treatment

A personalized peptide-receptor radionuclide therapy (PRRT) can help to improve radiation delivery for treating neuroendocrine tumors.

Neuroendocrine cancer can be exceedingly difficult to manage and can be unlikely to be cured. A research team from the Society of Nuclear Medicine has intended to slow down the progression of these tumors and aid survival by personalizing the patient dose of peptide-receptor radionuclide therapy (PRRT).//

The research study has been presented at the 2017 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI).

Carcinoid Tumors - Carcinoid Syndrome - Symptoms, Signs, Diagnosis & Treatment
Carcinoid tumors is a benign tumor that results in carcinoid syndrome. Only 8 to 10% of all carcinoid tumors are associated with the carcinoid syndrome.

‘A personalized peptide-receptor radionuclide therapy (PRRT) can improve radiation delivery for neuroendocrine tumor treatment.’

PRRT has become a treatment of choice for relatively rare and easy-to-overlook neuroendocrine tumors (NETs). The targeted treatment is designed to home in on and attach to peptide-receptor positive tumors, while sparing tissues that might otherwise be damaged by systemic treatments. However, researchers are still perfecting the practice.

"So far, the majority of PRRT treatments have been administered one-size-fits-all, meaning every patient receives about the same amount of radioactivity," said Jean-Mathieu Beauregard, MD, assistant professor in the Department of Radiology and Nuclear Medicine at Université Laval in Quebec City, Quebec, Canada. "This results in highly variable absorbed radiation doses to organs and tumors. Many patients may not draw the maximum benefits from PRRT because they end up receiving a lesser dose than their body can realistically tolerate."

For this study, researchers used a PRRT called lutetium-177 (177Lu)-octreotate, which mimics the somatostatin growth-inhibiting hormone. Ordinarily, patients receive a fixed amount of radioactivity, such as 200 millicuries, in several sequential cycles.

Anti-tumor Drug Variations Prove Effective for Cancer Treatment
Variations of anti-tumor agents like epothilones could be effective even for drug-resistant cancer treatment.

This marks the first time that 177Lu-octreotate PRRT has been matched to the patient's individual tolerance based on finely tuned SPECT dosimetry that evaluates how much radiation is building up in key organs like the kidneys.

A total of 27 neuroendocrine cancer patients underwent 55 personalized 177Lu-octreotate cycles from April to December 2016, followed by quantitative SPECT dosimetry. Radiation dose was quantified for the kidneys to optimize the administered amount of radioactivity, while remaining safe and well tolerated by patients.

Radiation Therapy Increases Complication in Breast Cancer Patients
Radiation therapy affects the options and outcomes for breast reconstruction, which many women who receive mastectomy desire.

Side effects were recorded and blood counts, as well as renal and hepatic biochemistry, were performed at two, four and six weeks after each cycle of treatment. Results showed an increase in the radiation dose to tumors for a majority of participants--increases as high as three times the dose delivered with conventional PRRT. Furthermore, serious side effects and toxicity remained infrequent with the personalized approach.

Additional research is planned for the coming months to determine how personalized PRRT results in improved therapeutic benefits, such as reduced tumor progression and longer survival.

Targeted Radiation Therapy-Viable Option For Elderly With Lung Cancer
Stereotactic body radiation therapy is a viable option for elderly patients who may otherwise be offered no curative treatment.

Source-Eurekalert