About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Multiple Sclerosis Drug Mitoxantrone Increases Colon Cancer Risk

by Reshma Anand on May 12, 2016 at 6:08 PM
Font : A-A+

Mitoxantrone is used for aggressive types of relapsing-remitting or progressive Multiple Sclerosis that do not respond to other MS drugs. But a new study has revealed that the drug may be associated with an increased risk of colorectal cancer.

Mitoxantrone suppresses the immune system. It was first developed as a chemotherapy drug for certain cancers. But its use is limited because previous studies have shown an increased risk of leukemia and heart damage.

Advertisement

Multiple Sclerosis Drug Mitoxantrone Increases Colon Cancer Risk
Multiple Sclerosis Drug Mitoxantrone Increases Colon Cancer Risk

The current study published in the journal Neurology examined whether the drug increases the risk of other types of cancer. For the study, German researchers looked at all people with MS who were treated with mitoxantrone from 1994 to 2007 and followed them until 2010.

Of the 676 people, 37 people, or 5.5 percent, were diagnosed with cancer after taking the drug, including nine people with breast cancer, seven with colorectal cancer and four with acute myeloid leukemia, which has been associated with mitoxantrone.
Advertisement

The rate of leukemia was 10 times higher in the people treated with mitoxantrone than in the general population in Germany. The rate of colorectal cancer, which is cancer of the colon and rectum, was three times higher than that of the general population. For breast cancer and all other types of cancer, people who had taken mitoxantrone were no more likely to develop the diseases than those in the general population.

Of the seven people with colorectal cancer, three died from the cancer during the study. The four people with leukemia all went into remission after treatment and were alive at the end of the study.

The researchers also looked at whether factors such as how much of the drug people had received cumulatively and whether they also received other immunosuppressant drugs affected their risk of developing cancer. The only factor related to a higher risk of cancer was being older when starting to take the drug.

"Despite an increased risk of acute myeloid leukemia and colorectal cancer, the overall rate of cancer was low enough to justify still using this drug for people severely affected by MS if no better treatment is available," said study author Mathias Buttmann, of the University of Würzburg in Würzburg, Germany.

"Mitoxantrone is the only approved treatment for people with secondary progressive MS without relapses and should be considered in people where the disease is evolving quickly. Also, many of the new and highly effective MS drugs are not available to people in a number of countries for economic reasons, so mitoxantrone is being used for people with very active relapsing forms of the disease."

Buttmann noted that the study was relatively small and needs to be confirmed. If the results are confirmed, he said that colonoscopies should be given after treatment with the drug to screen for colorectal cancer, which can be treated more effectively when diagnosed earlier.

Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
Test Your Knowledge on Sugar Intake and Oral Health
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Cancer and Homeopathy Colo-rectal cancer - Management Colorectal Cancer Chemotherapy Chemotherapy Drugs Signature Drug Toxicity Cancer Facts Cancer Tattoos A Body Art 

Most Popular on Medindia

Hearing Loss Calculator Turmeric Powder - Health Benefits, Uses & Side Effects Blood Donation - Recipients Selfie Addiction Calculator The Essence of Yoga Post-Nasal Drip Noscaphene (Noscapine) Color Blindness Calculator Drug Interaction Checker Daily Calorie Requirements
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Multiple Sclerosis Drug Mitoxantrone Increases Colon Cancer Risk Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests