Metastasis is responsible for 90% of cancer deaths and understanding the mechanisms responsible for this process is one of the prime objectives of the research.
Researchers Identify a Treatment That Prevents Tumor Metastasis
Metastasis, the strategy adopted by tumor cells to transform into an aggressive form of cancer, are often linked with a gloomy prognosis.
Metastasis, the strategy adopted by tumor cells to transform into an aggressive form of cancer, are often linked with a gloomy prognosis.
Researchers compared the genetic material in the primary tumor’s cells with the genetic material from metastasized cells in the same patient. Looking for differences, they found that among all patient’s genes, there is just one that clearly differs between those two groups. That gene, known as TBC1D16, in the initial tumor is inactive or dormant, while in the metastasized phase it is still active.
Esteller said, "This gene turns on like a light-bulb to guide metastasis and cause those cells to escape from their birth site. Specifically, what this gene does is to activate two more potent oncogenes, BRAF and EGFR, thus stimulating metastasis. There is already a drug on the market that acts against these oncogenes and another is currently in clinical trials. The next step is to convince pharmaceutical companies to include the TBC1D16 marker in their clinical trials."
Random Nature of Metastasis Revealed in New Study
A new study has shown for the spread of a cancer tumor from one part of the body to another could occur through pure chance, not genetic mutation
A new study has shown for the spread of a cancer tumor from one part of the body to another could occur through pure chance, not genetic mutation
Source-Medindia
Researchers Create New Tool to Unravel the Mysteries of Metastasis
If one could do this with all the circuit components, then this would allow people to learn how the circuitry is built.
If one could do this with all the circuit components, then this would allow people to learn how the circuitry is built.
Tumor Activated Protein Promotes Metastasis
Researchers report that cancers physically alter cells in the lymphatic system – a network of vessels that transports and stores immune cells throughout the body – to promote the spread of disease, a process called metastasis.
Researchers report that cancers physically alter cells in the lymphatic system – a network of vessels that transports and stores immune cells throughout the body – to promote the spread of disease, a process called metastasis.
