About Careers Internship MedBlog Contact us

A Gene Called TBC1D16 Responsible for Metastasis of Tumor That Leads to Cancer Deaths

by Dr. Trupti Shirole on June 3, 2015 at 8:16 AM
A Gene Called TBC1D16 Responsible for Metastasis of Tumor That Leads to Cancer Deaths

Metastasis is the spread of cancer cells from their original location to other parts of the body. A new study has found the mechanism of metastasis.

The study headed by Manel Esteller, the director of the Cancer Epigenetics and Biology Program at the Bellvitge Biomedical Research Institute in Barcelona, Spain, was conducted on melanomas, a malignant tumor associated with skin cancer, but the researchers found that this mechanism is also found in colon and breast cancer.


Esteller said, "Metastasis is responsible for 90% of cancer deaths and understanding the mechanisms responsible for this process is one of the prime objectives of the research."

Researchers compared the genetic material in the primary tumor's cells with the genetic material from metastasized cells in the same patient. Looking for differences, they found that among all patient's genes, there is just one that clearly differs between those two groups. That gene, known as TBC1D16, in the initial tumor is inactive or dormant, while in the metastasized phase it is still active.

Esteller said, "This gene turns on like a light-bulb to guide metastasis and cause those cells to escape from their birth site. Specifically, what this gene does is to activate two more potent oncogenes, BRAF and EGFR, thus stimulating metastasis. There is already a drug on the market that acts against these oncogenes and another is currently in clinical trials. The next step is to convince pharmaceutical companies to include the TBC1D16 marker in their clinical trials."

The study will be published in the Nature Medicine.

Source: Medindia
Font : A-A+



Recommended Readings

Latest Cancer News

Kinase-Targeted Therapy Revolutionizes Colorectal Cancer Care
Uncovering key kinases in tumor growth and invasion is crucial for improving targeted therapies in advanced-stage colorectal cancer.
Novel Photo-Oxidation Therapy Holds Promise for Anticancer Treatment
The study findings validate metal-enhanced photo-oxidation for future metal-based anticancer drugs.
Mutations in 11 Genes Linked to Aggressive Prostate Cancer
Mutations in 11 genes are linked to aggressive forms of prostate cancer, which may present novel therapeutic and therapy options.
Link Between Poor Oral Health and Head & Neck Cancer Survival Uncovered
Improved oral health, as indicated by the count of natural teeth and dental appointments preceding the diagnosis, correlated with enhanced head and neck cancer survival rates.
Painless Lumps in the Body May Signal Lymphatic Cancer Risk
The presence of painless swelling in the lymph nodes could potentially indicate lymphatic cancer, say experts.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
Greetings! How can I assist you?MediBot

A Gene Called TBC1D16 Responsible for Metastasis of Tumor That Leads to Cancer Deaths Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests