About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Major Inflammatory Players Revealed in Diabetic Kidney Disease

by Julia Samuel on April 11, 2016 at 1:40 PM
Font : A-A+

Major Inflammatory Players Revealed in Diabetic Kidney Disease

Certain key inflammatory mechanisms underlying type 1 diabetes and obesity-related kidney dysfunction have been identified by a multi-disciplinary team led by researchers at University of California, San Diego School of Medicine.

"We found that insulin deficiency and insulin resistance, two hallmarks of diabetes, seem to be associated with increased sphingomyelin in the kidney, which trigger damaging inflammatory mechanisms," said senior author Kumar Sharma, MD, professor of medicine and director of the UC San Diego School of Medicine Institute of Metabolomic Medicine (IMM) and Center for Renal Translational Medicine (CRTM).

Advertisement


In the study, the researchers analyzed the kidneys of experimental mice with type 1 diabetes and mice fed a high-fat diet. They found increased amounts of sphingomyelin, a type of fatty acid commonly found in cell membranes and nervous tissue, in both experimental groups.

Specifically, Sharma said, the sphingomyelin are believed to drive an increase in the ratio of adenosine triphosphate (ATP) and adenosine monophosphate-activated protein (AMP) in glomerular cells of the kidney in mice with diabetes, obesity or both. ATP/AMP are molecules involved in intracellular energy transfer and glomerular cells are key in the filtering and cleansing of blood, one of the primary functions of the kidney.
Advertisement

"ATP is involved in every cellular function. It is the energy currency of the cell," said Sharma. "But too much ATP causes inflammation. We believe that sphingomyelin fuels increases in ATP and decreases in AMP that result in inflammation which leads to cell dysfunction, fibrosis and endothelial damage underlying diabetic kidney disease."

Normally, ratios of ATP and AMP are tightly regulated, depending on energy needs of the cell. "The mechanisms triggered by diabetes and obesity, such as increased ATP, seem to disrupt that balance."

Previously, it was not known exactly how ATP was affected in this process. "Due to difficulties in the stability of ATP, it was uncertain whether there was increased ATP or decreased ATP production with diabetes," Sharma said, adding that the investigators used mass spectrometry imaging to answer this question by identifying these difficult to measure molecules in frozen tissues.

Diabetic kidney disease is the leading cause of end-stage kidney disease, the eighth leading cause of death in the United States and a major risk factor for cardiovascular disease. An estimated 26 million American adults have chronic kidney disease, often requiring dialysis or a kidney transplant.

The study's insights could have major impact on developing new biomarkers and novel therapeutics for diabetic and obesity-related complications, such as kidney disease, said Sharma. "It may be possible to create new treatments by blocking ATP and the inflammatory pathways consequent to that or by developing ways to reduce the amount or activity of sphingomyelin in the kidney."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
World Disability Day 2022 - The Role of Innovative Transformation
Diet and Oral Health: The Sugary Connection May Become Sour
World AIDS Day 2022 - Equalize!
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetes - Self-Monitoring of Blood Glucose (SMBG) Diabetes and Exercise Urinary Stones In Children Vesico-Ureteric Reflux Causing UTI in Children Hydronephrosis / Antenatal Counseling Kidney Disease Kidney Pregnancy and Complications Glycemic Index Type 2 Diabetes 

Most Popular on Medindia

Loram (2 mg) (Lorazepam) Blood Pressure Calculator Turmeric Powder - Health Benefits, Uses & Side Effects Iron Intake Calculator Drug Interaction Checker Sanatogen Calculate Ideal Weight for Infants Drug - Food Interactions Find a Hospital Sinopril (2mg) (Lacidipine)
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Major Inflammatory Players Revealed in Diabetic Kidney Disease Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests