About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Lung Disease Drugs Work With Body Clock

by Kathy Jones on July 28, 2014 at 10:05 PM
Font : A-A+

 Lung Disease Drugs Work With Body Clock

Researchers at University of Manchester suggest that drugs used in treating lung diseases, such as asthma and pneumonia, work with the body clock and this may be one of the reasons why they become ineffective.

In the UK pneumonia, which is caused by an infection, affects around 1 in 1000 adults each year and is more serious for babies, young children, the elderly, smokers and those with an underlying health condition.

Advertisement

More than 5 million people in the UK are affected by asthma and the NHS spends around Ģ1 billion a year treating and caring for people with the disease.

The research, led by Professors David Ray and Andrew Loudon from The University of Manchester, found out that cells lining the lung airways have their own body clock which is the time-keeper for lung inflammation - both conditions cause swelling (inflammation) in the lungs.
Advertisement

And the team discovered that more severe lung inflammation happens as a result of the loss of the body clock working in these cells.

Professor Loudon said: "We found a key molecule known as CXCL5 that facilitates lung inflammation which is a key regulator of how immune cells get into tissues. The loss of CXCL5 completely prevents the time of day regulation of lung inflammation which opens up new ways to treat lung diseases."

During the research, the team uncovered how glucocorticoid hormones from the adrenal gland are vital in controlling the level of inflammation in the cells lining the airway.

Professor Ray said: "This hormone works through the glucocorticoid receptor, a major regulator of gene expression. We wanted to find out therefore if glucocorticoid medicines, like prednisolone or dexamethasone would also show a time of day effect, and our research shows they do."

The team concluded that the rhythm of the clock in the lining of the cells in the lungs is important for lung diseases like asthma, and chronic obstructive pulmonary disease.

Professor Loudon said: "In this work we define a major circadian control on lung inflammation which affects responses to bacterial infection, or pneumonia. We know that many lung diseases indeed show a strong time of day effect, including asthma, and deaths from pneumonia."

Our bodies anticipate the change from day to night by having an internal, or circadian clock. This explains why it is hard to adjust to shift work. The body clock regulates sleep, but now has been discovered to also regulate our immune system.

"We live in a world that is divided into day and night. As a result our behaviour varies by time of day; we sleep at night, and are active, and eat during the day. Increasingly our lives are disconnected from this ancient rhythm, with artificial light, shift work, and jet lag," concluded Professor Ray.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Contraceptive Pills in Polycystic Ovary Syndrome (PCOS) Curtail Type 2 Diabetes Risk
Mushroom May Help Cut Down the Odds of Developing Depression
How to Battle Boredom during COVID
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Sarcoidosis / Besnier - Boeck disease Asbestosis Pneumoconiosis Healthy Living Drugs Banned in India Silicosis Pneumonectomy 

Recommended Reading
Congenital Cystic Adenomatoid Malformation Of The Lung
Congenital disease of the lung in which multiple cysts (water bubbles) develop in the lung tissues, ...
Lung Biopsy
The procedure by which tissue samples are obtained from the lung is known as lung biopsy. The ......
Asthma
It's a lung condition characterized by inflammation of the bronchi and constriction of the airways ....
Asbestosis
Asbestosis is a chronic inflammatory lung disease that occurs due to long term exposure to asbestos ...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....
Pneumoconiosis
Pneumoconiosis is a group of lung diseases caused by inhaled dust particles. It causes inflammation ...
Sarcoidosis / Besnier - Boeck disease
Bernie Mac the comedian died of complications arising from Sarcoidosis, a little known immune system...
Silicosis
Silicosis is a lung disease caused by inhalation of crystalline free silica dust. It is characterise...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use