About Careers MedBlog Contact us

Latent Herpes Virus Infection can be Treated With Tranylcypromine (TCP)

by Dr. Trupti Shirole on December 5, 2014 at 9:41 AM
Font : A-A+

 Latent Herpes Virus Infection can be Treated With Tranylcypromine (TCP)

Researchers have found an effective treatment approach to inhibit and keep the latent herpes simplex virus from reactivating and causing disease with the help of an existing drug, tranylcypromine (TCP), which blocked a protein called LSD1 that plays a major role in the initiation of herpes simplex virus infection.

Current treatments require active viral replication and targets late stages of the infection, which has led to development of drug resistance. This study took a different approach by targeting a drug, TCP, to a protein that controls how genes are turned on and off, early in the viral replication process. This epigenetic approach reduced symptoms and also reduced shedding (i.e. release of virus particles which can transmit the virus even in the absence of symptoms) and forced the virus to remain in a latent stage, preventing its reactivation. Thus, indicating that even when a virus is not active, drugs modulating epigenetic changes can still treat the infection.


This multi-institutional animal study was conducted by late James Hill, PhD, LSU Health New Orleans Professor and Director of Pharmacology and Infectious Disease at the LSU Eye Center, who was the lead author for the study, Thomas M. Kristie, PhD, Chief of the Molecular Genetics Section in the National Institute of Allergy and Infectious Diseases' Laboratory of Viral Diseases, led the study, and also included Timothy Foster, PhD, LSU Health New Orleans Associate Professor of Microbiology, Immunology & Parasitology.

The study is published in Science Translational Medicine.

Source: Medindia

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Latent Herpes Virus Infection can be Treated With Tranylcypromine (TCP) Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests