Lack of RNA Editing in Melanoma Leads to Tumor Growth and Progression

Scientists at The University of Texas MD Anderson Cancer Center have revealed that lack of RNA editing, a process by which information inside RNA molecules is transformed, in melanoma leads to tumor growth and progression through manipulation of proteins.

Study lead Menashe Bar-Eli reported a previously unknown target for CREB (cAMP response element-binding protein), a transcription factor (proteins that turn genetic instructions on and off) that regulates other transcription factors involved in melanoma development. Bar-Eli said, "We found that CREB regulates ADAR1, an enzyme involved in RNA editing. CREB negatively regulated ADAR1, promoting melanoma tumor growth and metastasis. When we discovered that CREB negatively regulated ADAR1, we looked further into how the loss of ADAR1 expression contributes to the cancer spread."