In "Ivacaftor Is Associated with Reduced Lung Infection by Key Cystic Fibrosis Pathogens: A Cohort Study Using National Registry Data," researchers in the U.K. report that ivacaftor may also reduce some of the most common lung infections in patients with CF, including P. aeruginosa. If this is true, they say, it may mean that some patients taking ivacaftor can take fewer antibiotics long term and still remain clinically stable.
‘Patients with cystic fibrosis could potentially take fewer antibiotics and remain clinically stable upon regular intake of ivacaftor.’
"People with CF notice improvement in lung function and quality of life soon after they start taking ivacaftor, but they still have to live with a considerable treatment burden from all the other medications they take," said lead author Freddy Frost, BMBS, a cystic fibrosis physician at Liverpool Heart & Chest Hospital. "At present, we simply don't know whether it's safe to stop some of those other treatments. The fact we have seen reduced infections in this study suggests there may be some people who can safely discontinue medications targeted towards those infections."
Using data from a CF registry in the U.K., the authors compared CF patients (age six and older) who took ivacaftor with those CF patients who did not take the drug over a three-year period.
The study found that ivacaftor was associated with a 32 percent reduction in the number of people infected with P. aeruginosa and a 15 percent reduction in Staphylococcus aureus. These reductions resulted from both increased clearance of the infection in those already infected and in reduced acquisition in those not infected.
The authors said that with people starting ivacaftor and other drugs that correct defects in the CF gene from an early age, the possibility of preventing these infections is particularly exciting. "If these drugs are taken before chronic infection starts, the risk of developing infection in the future may be reduced considerably," Dr. Frost said.
Ivacaftor was also associated with reduced Aspergillus spp. infections. The drug did not appear to reduce Burkholderia cepacia complex infections.
Dr. Frost said that the study adds to the increasing evidence of the long-term benefits of ivacaftor. "However," he added, "randomized, controlled trials will be needed to know if it is safe to reduce the overall treatment burden of CF by decreasing antibiotic use in patients taking ivacaftor or other drugs that target defects in the CF gene."
Source: Eurekalert
