About Careers MedBlog Contact us

Italian Doctor Takes His Campaign For Neck Vein Surgery For MS To Canada

by Gopalan on June 17, 2010 at 11:21 AM
Font : A-A+

 Italian Doctor Takes His Campaign For Neck Vein Surgery For MS To Canada

Italian doctor Paolo Zamboni has taken to Canada his campaign for surgery of blocked neck veins as a treatment option for multiple sclerosis (MS).

Talking to MPs on the House of Commons health committee on Tuesday through video conferencing, the crusading doctor said the vein procedure should be offered in a randomized clinical trial under the supervision of an ethical committee.


He maintains the procedure, also known as liberation therapy, has resulted in better cognitive and motor function. The endovascular surgical procedure involves inserting a tiny balloon or stent into blocked veins in order to improve the flow of blood out of the brain and spinal cord.

His quest for an effective treatment of MS started when his wife Elena Ravalli became a victim back in 1995. Though seemingly healthy at 37 years, she began to experience strange attacks of vertigo, numbness, temporary vision loss and crushing fatigue. They were classic signs of multiple sclerosis, a potentially debilitating neurological disease.

Dr. Paolo Zamboni, a professor of medicine at the University of Ferrara in Italy, set out to solve the mystery of MS - an illness that strikes people in the prime of their lives but whose causes are unknown and whose effective treatments are few.

Using ultrasound to examine the vessels leading in and out of the brain, Dr. Zamboni made a startling find: In more than 90 per cent of people with multiple sclerosis, including his spouse, the veins draining blood from the brain were malformed or blocked. In people without MS, they were not.

His research made him conclude MS was not an autoimmune condition, but a vascular disease. Zamboni calls the condition "chronic cerebrospinal venous insufficiency," or CCSVI.

He hypothesized that iron was damaging the blood vessels and allowing the heavy metal, along with other unwelcome cells, to cross the crucial brain-blood barrier. (The barrier keeps blood and cerebrospinal fluid separate. In MS, immune cells cross the blood-brain barrier, where they destroy myelin, a crucial sheathing on nerves.)

More striking still was that, when Dr. Zamboni performed a simple operation to unclog veins and get blood flowing normally again, many of the symptoms of MS disappeared. The procedure is similar to angioplasty, in which a catheter is threaded into the groin and up into the arteries, where a balloon is inflated to clear the blockages. His wife, who had the surgery three years ago, has not had an attack since.

The researcher's theory is simple: that the underlying cause of MS is a condition he has dubbed "chronic cerebrospinal venous insufficiency." If you tackle CCSVI by repairing the drainage problems from the brain, you can successfully treat, or better still prevent, the disease.

On June 11, 2010, the US National MS Society and MS Society of Canada announced a commitment of over $2.4 million to support 7 initial CCSVI grants to determine the role of CCSVI in the MS disease process. Further studies are also taking place at centers including University at Buffalo Medical Center and the Center for Vascular Awareness in Albany, NY.

The National MS Society pf the US said it shares the public's sense of urgency to expeditiously advance any lead that has the potential of stopping, repairing or preventing MS. Accordingly, the Society is pursuing this new and potentially promising research direction by committing to fund expanded research on CCSVI in MS.

The MS Society of Canada announced last week that it is spending $700,000 on four studies to determine if there is a link between blocked veins and MS, before it will support surgical treatment. The society says researchers elsewhere in the world haven't been able to reproduce Zamboni's findings.

The society wants more people assessed for blockages that are objectively evaluated by doctors, said spokeswoman Karen Lee.

Research needs to include people who receive vein treatment to see whether they improve, just as a drug therapy would be compared with a placebo, said Dr. Robert Maggisano, a vascular surgeon at Sunnybrook Health Sciences Centre in Toronto.

"We're wasting time and money, and certainly not helping our people, who are going overseas to get treatment, when we should be able to do the studies in a blinded fashion within Canada," Maggisano said.

Alain Beaudet, president of the Canadian Institutes of Health Research, said the institute is seeking proposals for a blinded, randomized control trial that includes the procedure. The deadline for proposals is mid-August.

Source: Medindia

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Italian Doctor Takes His Campaign For Neck Vein Surgery For MS To Canada Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests