New data has been collected on the safety of benznidazole drug, which is used commonly to treat Chagas disease.
Knowledge about its toxicity profile is scarce and mostly based on post-marketing observational studies.
Benznidazole is one of the two existing antiparasitic drugs for Chagas' disease treatment. However, it is a poorly tolerated drug and its use to treat chronic disease raises safety concerns.
Adverse reactions were observed in 85 of the 99 participants, with an average of three adverse reactions per patient.
Most adverse reactions (90%) were mild and appeared in the first month of treatment.
The researchers also identified some unexpected adverse reactions that were not described previously, such as sleeping disorders and anxiety.
"These results confirm that, with the most widely used dosage and regimen, there is a high frequency of adverse reactions to benznidazole" says Maria Jesús Pinazo, ISGlobal researcher and study co-author.
"Until we have something better, benznidazole will remain part of the treatment in the near future, so these results underline the urgent need to find ways to combine it with other drugs or use different dosages in order to achieve maximum efficacy with the minimum toxicity", she adds.