Hydroxychloroquine was found to be not very effective in treating moderate to severe hand pain and radiographic osteoarthritis, reveals a new study.
The findings of a randomized trial were published in Annals of Internal Medicine.
Lifestyle And Osteoporosis
Encyclopedia section of medindia briefly explains about Lifestyle and Osteoporosis
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‘Severe hand pain could not be treated effectively with the use of off-label drug hydroxychloroquine.’
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Symptomatic hand osteoarthritis affects up to 31 percent of adults over the age of 70 and up to 15 percent of those over the age of 60.
The pain can be debilitating and few therapies are effective. As such physicians seek alternatives to improve quality of life for patient suffering from hand osteoarthritis.
![Osteogenesis Imperfecta]( "Osteogenesis Imperfecta")
Encyclopedia section of Medindia gives general info about Osteogenesis Imperfecta
Hydroxychloroquine has been used as an off-label treatment, but data on its efficacy is sparse.
Researchers from the Leeds Institute of Rheumatic and Musculoskeletal Medicine and NIHR Leeds Biomedical Research Centre randomly assigned 248 participants with symptomatic and radiographic hand osteoarthritis to either hydroxychloroquine (200 to 400 mg) or placebo for 12 months with ongoing usual care.
The goal was to determine the effectiveness of hydroxychloroquine versus placebo as an analgesic treatment.
At 6 months, mean hand pain was 5.49 points in the placebo group and 5.66 points in the hydroxychloroquine group.
The authors concluded that hydroxychloroquine was no more effective than placebo for pain relief.
According to the researchers, these findings do not support the current practice of off-label use of hydroxychloroquine in patients with hand osteoarthritis.
The researchers also noted that a lot of hand pain may be caused by tendon problems, rather than arthritis, which hydroxychloroquine would not have helped.
Source: Eurekalert
Osteogenesis Imperfecta
Encyclopedia section of Medindia gives general info about Osteogenesis Imperfecta
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Hydroxychloroquine has been used as an off-label treatment, but data on its efficacy is sparse.
Researchers from the Leeds Institute of Rheumatic and Musculoskeletal Medicine and NIHR Leeds Biomedical Research Centre randomly assigned 248 participants with symptomatic and radiographic hand osteoarthritis to either hydroxychloroquine (200 to 400 mg) or placebo for 12 months with ongoing usual care.
The goal was to determine the effectiveness of hydroxychloroquine versus placebo as an analgesic treatment.
At 6 months, mean hand pain was 5.49 points in the placebo group and 5.66 points in the hydroxychloroquine group.
The authors concluded that hydroxychloroquine was no more effective than placebo for pain relief.
According to the researchers, these findings do not support the current practice of off-label use of hydroxychloroquine in patients with hand osteoarthritis.
The researchers also noted that a lot of hand pain may be caused by tendon problems, rather than arthritis, which hydroxychloroquine would not have helped.
Source: Eurekalert
Avascular Necrosis
Avascular necrosis or Osteonecrosis affects the bone and occurs because of the interruption to its blood supply resulting in bone death and leading to secondary osteoarthritis.
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 Diet, Nutrition and Supplements for Osteo-Arthritis and Rheumatoid ArthritisRheumatoid arthritis patients should consume a diet rich in natural antioxidant and anti-inflammatory nutrients and avoid foods like sugar, saturated fats, and trans fatty acids. | Advertisement
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