MRI Technique to Identify the Type of Breast Cancer Tissue

MRI breast imaging technique does not require any contrast agents like gadolinium or sophisticated data to differentiate between benign and malignant tumor.

Diffusion kurtosis imaging is a type of MRI breast imaging technique that does not require any contrast agents or sophisticated data to identify the cancer tissue and it also reduces the number of breast biopsies, says a study published in the journal Radiology.

Breast MRI currently is used to screen women at high risk of breast cancer and as a diagnostic adjunct to mammography. The examination relies on gadolinium-based contrast agents that need to be injected intravenously.

‘MRI imaging technique reduces the number of breast biopsies and use of contrast agents that are injected intravenously. ’

Researchers recently studied an alternative approach that eliminates the need for contrast agents in some cases by using diffusion-weighted imaging (DWI) measurements derived from MRI. The technique, known as diffusion kurtosis imaging, provides a picture of breast tissue on a microstructural level.

"Diffusion kurtosis imaging has been introduced in DWI to provide important information on tissue structures at a microscopic level," said study lead author Sebastian Bickelhaupt, M.D., from the German Cancer Research Center in Heidelberg, Germany. "Since malignant lesions disrupt the tissue structures at this level, diffusion kurtosis might serve as a relevant marker of changes."

Dr. Bickelhaupt, co-lead author Paul Jaeger, M.Sc., and colleagues evaluated a retrospective analysis of data collected from 222 women at two independent study sites. The women had suspicious findings on mammography that were classified under the Breast Imaging Reporting and Data System (BI-RADS) as BI-RADS 4 and 5 breast lesions. A BI-RADS 4 lesion is considered a suspicious abnormality, while a 5 is considered highly suspicious of malignancy. The women underwent DWI followed by biopsy.

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For the analysis, a software algorithm was developed for lesion characterization, and imaging features were extracted using a kurtosis-based radiomics model. Radiomics is a rapidly growing field that enables the extraction of a large amount of quantifiable data from images.

In an independent test set of 127 women, the radiomics analysis reduced false-positive findings by 70 percent, while detecting 60 of 61 malignant lesions, or 98 percent.