About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

MRI Technique to Identify the Type of Breast Cancer Tissue

by Shravanthi Vikram on February 20, 2018 at 11:27 AM
Font : A-A+

MRI Technique to Identify the Type of Breast Cancer Tissue

Diffusion kurtosis imaging is a type of MRI breast imaging technique that does not require any contrast agents or sophisticated data to identify the cancer tissue and it also reduces the number of breast biopsies, says a study published in the journal Radiology.

Breast MRI currently is used to screen women at high risk of breast cancer and as a diagnostic adjunct to mammography. The examination relies on gadolinium-based contrast agents that need to be injected intravenously.

Advertisement


Researchers recently studied an alternative approach that eliminates the need for contrast agents in some cases by using diffusion-weighted imaging (DWI) measurements derived from MRI. The technique, known as diffusion kurtosis imaging, provides a picture of breast tissue on a microstructural level.

"Diffusion kurtosis imaging has been introduced in DWI to provide important information on tissue structures at a microscopic level," said study lead author Sebastian Bickelhaupt, M.D., from the German Cancer Research Center in Heidelberg, Germany. "Since malignant lesions disrupt the tissue structures at this level, diffusion kurtosis might serve as a relevant marker of changes."
Advertisement

Dr. Bickelhaupt, co-lead author Paul Jaeger, M.Sc., and colleagues evaluated a retrospective analysis of data collected from 222 women at two independent study sites. The women had suspicious findings on mammography that were classified under the Breast Imaging Reporting and Data System (BI-RADS) as BI-RADS 4 and 5 breast lesions. A BI-RADS 4 lesion is considered a suspicious abnormality, while a 5 is considered highly suspicious of malignancy. The women underwent DWI followed by biopsy.

For the analysis, a software algorithm was developed for lesion characterization, and imaging features were extracted using a kurtosis-based radiomics model. Radiomics is a rapidly growing field that enables the extraction of a large amount of quantifiable data from images.

In an independent test set of 127 women, the radiomics analysis reduced false-positive findings by 70 percent, while detecting 60 of 61 malignant lesions, or 98 percent.

"The model might help to lower the number of BI-RADS 4 lesions suspected of being cancer on the basis of screening mammography while retaining a high sensitivity similar to the sensitivity reported for biopsies themselves," Jaeger said.

Should the results hold in larger trials, the model has potential advantages in the clinic beyond its ability to reduce unnecessary biopsies in women with BI-RADS 4 lesions. The software algorithm makes the assessment reader-independent, ensuring that its accuracy is maintained across different imaging facilities.

The new approach is not intended to replace current contrast-enhanced breast MRI protocols in general, Dr. Bickelhaupt emphasized, but to expand the spectrum of options available for answering specific clinical questions.

"This might also improve the efficiency of reporting," he said.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Breast Biopsy Pagets disease of the breast Otitis Media Mastitis Magnetic Resonance Imaging Cancer and Homeopathy Breast Cancer Facts Cancer Facts Cancer 

Recommended Reading
New MRI Technique Provides Superior Imaging With Less Expensive Machines
A new technology harnesses imperfections that typically compromise MRI exams to create images ......
MRI Technique Quantifies Liver Response in Steatohepatitis Patients
NAFLD and NASH are invisible diseases. In most cases, adverse effects are not noticeable until the ....
New Super-fast MRI Technique Reveals Manner of How We Sing, Speak
MRI technique is far more advanced than any other MRI technique that could scan 100 frames per ......
Breast Biopsy
Breast biopsy involves removing a sample of breast tissue to determine whether it is cancerous or .....
Magnetic Resonance Imaging
Encyclopedia section of medindia gives general info about Magnetic Resonance Imaging...
Mastitis
Mastitis is a common cause of tenderness, swelling and pain in breast, owing to inflammation in the ...
Otitis Media
Middle ear infection, or otitis media, is a common type of infection that may or may not accompany t...
Pagets disease of the breast
A detailed description of the Paget's disease of the breast, characteristic signs and symptoms, dete...
Women and Cancer
Cancer is one of the frequently talked about and most feared disease that falls under the genre of l...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use