About My Health Careers Internship MedBlogs Contact us

Indian Researcher Has Identified Key Enzyme’s Role in Reducing Heart Disease

by Medindia Content Team on October 25, 2007 at 6:35 PM
Font : A-A+

Indian Researcher Has Identified Key Enzyme’s Role in Reducing Heart Disease

A research team led by an Indian researcher has identified a key enzyme's role in reducing heart disease which could pave way for new target therapies to reduce plaques in the arteries.

It is due to the formation of plaques in the coronary artery, which supplies blood to the heart, that heart diseases develop.


Plaques form when monocytes, which are cells from the blood, enter the wall of the artery and consume large amounts of the 'bad' cholesterol, or LDL. The monocytes then become artery-clogging foam cells.

For foam cells to get rid of their cholesterol is to by making it available to HDL, or 'good' cholesterol, for removal.

Cholesteryl ester hydrolase (CEH), a key enzyme present in the foam cells regulates the amount of cholesterol that can be removed by HDL.

A macrophage foam cell contained fat droplets that are surrounded by CEH showing how the enzyme associates itself with fat and releases cholesterol to be picked up by HDL.

The study led by Shobha Ghosh, Ph.D., an associate professor of internal medicine, researchers at the pulmonary division in the VCU School of Medicine examined, for the first time, how cells in the artery wall make cholesterol available for removal by HDL.

In the research transgenic mice were used which were fed a high fat and cholesterol-rich diet. Because of this, the team was able to show that by increasing the removal of cholesterol from the artery clogging foam cells, the mice with the human gene for CEH developed significantly less heart disease.

"Currently the emphasis for managing heart disease is on reducing the 'bad' cholesterol or LDL in the circulation. Our study demonstrates that if you can increase the removal of cholesterol from the plaques, even without changing the LDL levels, there is still a significant reduction in the plaques," Ghosh said.

"These findings not only change the current thinking of managing heart disease but also clearly open avenues for the development of new therapies," she said.

"By identifying CEH as a new therapeutic target, we expect that in the future patients with heart disease will have more options to aggressively treat heart disease. In addition, by determining the levels of CEH in human blood cells, we hope to be able to predict susceptibility to heart disease in the future," she added.

The finding may also help in predicting a patient's susceptibility to heart disease.

Ghosh said that in the study the efforts were on the examination of macrophage foam cells, which are responsible for storing large amounts of cholesterol and lead to the clogging of the arteries by forming plaques.

The study is published in the Journal of Clinical Investigation.

Source: ANI

News A-Z
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cardiac Catheterization Heart Attack Air travel: To fly or not to fly Diet Lifestyle and Heart Disease Silent Killer Diseases Heart Healthy Heart Statins Mitral Valve Prolapse Aortic Valve Stenosis 

Recommended Reading
World Heart Day – ‘Team Up for Healthy Hearts’
The heart, often called the 'seat of emotions, thought, and creativity' by many scientists and ......
Coronary Artery Bypass Graft (CABG) - Triple Bypass Surgery
Triple bypass surgery, an open heart surgery involves grafting blood vessels from either the chest ....
Air travel: To fly or not to fly
Air travel is for everyone, even those with medical conditions....
Aortic Valve Stenosis
Aortic valve Stenosis is an abnormal narrowing of the c valve. Symptoms include angina, and that of ...
Cardiac Catheterization
Cardiac catheterization is a radiological procedure for both diagnosis and treatment of heart condit...
Heart Attack
Heart attack is the death of the heart muscle due to loss of blood supply. Heart disease is the lead...
Mitral Valve Prolapse
Mitral Valve Prolapse is a relatively common condition and causes leakage of blood through the valve...
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use