About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Immune System may Play a Negative Role in Brain Injuries and Other Disorders

by Kathy Jones on July 27, 2014 at 10:10 PM
Font : A-A+

 Immune System may Play a Negative Role in Brain Injuries and Other Disorders

Researchers at Cleveland Clinic suggest that the body's immune system may play a negative role in impairment and cognitive dysfunction among patients suffering from conditions such as chronic epilepsy, Alzheimer's disease and concussions, a new study published in the journal PLOS ONE reveals.

The study focuses on the role of a protein known as S100B, which serves as a biomarker for brain damage. Normally, S100B is found only in the brain and spinal column. However, following a brain injury, it can leak through the blood-brain barrier into the blood.

Advertisement

Once S100B enters the bloodstream, it is identified as an intruder by the immune system, which releases antibodies to attack the protein.

"Our results show an unexpected role for S100B in the regulation of a neuro-immune response, connecting the function of the brain to the immune system," said Damir Janigro, Ph.D., senior author and molecular medicine researcher at Cleveland Clinic's Lerner Research Institute. "Uptake of S100B was prominent in cells that are known to be involved in regulating immune responses. Repeated increases of S100B - whether due to epileptic seizures, Alzheimer's disease, or repeated hits to the head in sporting events - may thus become boosters of an autoimmune response against the brain, which may slowly but inexorably result in chronic neurological disease."
Advertisement

These findings are the first to report a connection between a brain-derived protein and an immune response in the context of normal immunological function.

"Prior to this research, S100B autoantibodies have been described in a variety of diseases, primarily in Alzheimer's dementia and chronic epilepsy. More recently, repeated subconcussive episodes in football players included a post-game increase of S100B, followed by an autoimmune response against the protein," Janigro said. "Therefore, it appears that autoimmunity against brain proteins may be one of the initial steps in the progression towards posttraumatic cognitive decline."

The study tested the hypothesis that the presence of S100B in extracranial tissue is due to the production of antigen-presenting cells in the blood, which may induce the production of auto-antibodies against S100B. To test this hypothesis, researchers used animal models of seizures, enrolled patients undergoing repeated disruption of the blood-brain barrier, and collected blood samples from epileptic patients.

If further research confirms the study's findings, treatments for brain injury may include anti-inflammatory therapy or immunomodulators to decrease the autoimmune response, as has been done in the treatment of multiple sclerosis and myasthenia gravis.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Parkinsons Disease Surgical Treatment Immunisation Brain Brain Facts Amyotrophic Lateral Sclerosis (ALS) Ataxia Myasthenia Gravis Leg Injuries and Disorders Language Areas in The Brain 

Recommended Reading
Brain Exercises to Improve Memory
An active brain can certainly help in improving memory by strengthening the connections between ......
Foods to Improve Memory Power
Eating healthy nutritious foods can help improve memory power and prevent brain-related illness. ......
Alzheimers Disease
Alzheimer's disease is a progressive neurodegenerative disease affecting memory and thinking and ......
Amyotrophic Lateral Sclerosis (ALS)
Find out more about the degenerative disease- Amyotrophic lateral sclerosis....
Ataxia
Ataxia affects coordination. Gait becomes unstable and the patient loses balance. The cerebellum or ...
Language Areas in The Brain
The mechanism of how human brain processes the language to express and comprehend the verbal, writte...
Leg Injuries and Disorders
Legs are easily prone to injuries while playing sports, running or falling. These injuries affect th...
Myasthenia Gravis
Myasthenia gravis is the commonest disorder of neuromuscular transmission. Autoimmune myasthenia gra...
Parkinsons Disease
Parkinson’s disease is a neurodegenerative disease caused by progressive dopamine brain cells loss. ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use