A research team from Imperial College in London, England have discovered that a new formulation of Ibuprofen might prove to be a wonder drug. The research study was published in Federation of American Societies for Experimental Biology Journal.
Scientists used animals like mice and rats to depict the use of the new ibuprofen formulation in people. Ibuprofen arginate can be taken in higher doses as it did not produce any cardiovascular side effects that are commonly found with over the counter products.
Ibuprofen arginate was found to provide faster pain relief and is rapidly released into the bloodstream when compared to the current formulations.
She also said that the findings may potentially be game-changing in the discovery of pain medication.
Different approaches by wide range of experiments using single type of cells to whole laboratory animals in which blood pressure could be measured was used.
The first approach was studied using mouse cells in dishes where arginine was removed from the growth solution. This was used to find that arginine present in ibuprofen arginine would work in the same way as regular arginine would work in the cells.
The second approach involved the use of blood vessels from mice and rats, to which artificial compound which blocks the protective action of normal arginine was applied. The resultsreported that ibuprofen arginine was able to reverse the block and restore normal blood vessel functions.
The third approach measured blood pressure in live rats by blocking protective effects of normal arginine which increased blood pressure. The results of the study reported that the new formulation of ibuprofen was found to work just like that of regular arginine to restore normal blood pressure levels.
High doses of common pain killers can result in cardiovascular side effects which could be prevented by using arginine form of ibuprofen.
Thoru Pederson, Ph.D., Editor-in-Chief of The FASEB Journal said "This is a nifty idea and the results are clear."
"The potential for human use is attractive, not only for attenuating the cardiovascular risk, but also to the extent that this formulation may circumvent moving certain patients onto opioid painkillers, fraught with their own dangers." he added.