How Does the Microbiome Affect Pancreatic Cancer Outcome?

Genetics and gut microbiome may help decipher why few patients with Pancreatic cancer have a longer survival rate. The findings are published in the journal Cancer. The microbiome is a term used for the collection of microbes, including microorganisms like bacteria, that live on or in the human body. Jordan Kharofa, MD, said there was little known about the microbiome of long-term pancreatic cancer survivors.

“There is emerging science suggesting that pancreas cancer survivors have a robust immune response in their tumors and data suggests the gut microbiome can influence immune response,” said Kharofa, University of Cincinnati Cancer Center physician-researcher and associate professor in the UC College of Medicine’s Department of Radiation Oncology. “We wondered if there was a relationship with the gut microbiome in pancreatic cancer survivors.”

Exploring the Impact of the Microbiome on Pancreatic Cancer Outcomes

The research team analyzed microbiome data from pancreatic cancer survivors and a control group of pancreatic cancer patients. They found long-term survivors’ microbiomes had increased levels of several specific bacterial species including Faecalibacterium prausnitzii.

“Little information exists to help us understand why some patients are cured from pancreatic cancer and unfortunately most are not,” he said. “These species may help to promote immune response to pancreas cancer but this has not yet been proven.”

While it is still unknown exactly how or if these bacteria directly contribute to patients’ long-term survival, the species have been previously been associated with improved response to immunotherapy for patients with metastatic melanoma or skin cancer.

“There is a growing understanding that the microbiome is a part of the normal immune response. The importance of the microbiome in response to immunotherapy drugs in melanoma and other cancer types is well established,” Kharofa said.

Kharofa said these bacterial species have not been linked to any specific diet, lifestyle or genetic makeup that would give insight on how to naturally elevate levels in the microbiome. Some researchers have begun testing fecal transplants using stool from long-term survivors, and Kharofa said the Cancer Center team is in the early phase of exploring microbiome modulation through oral administration of bacterial species.

Source-Eurekalert