High Dose Folic Acid Does Not Prevent Pre-eclampsia in High Risk Women, Finds Study

by Colleen Fleiss on  September 13, 2018 at 1:22 PM Women Health News
RSS Email Print This Page Comment bookmark
Font : A-A+

Extra folic acid taken beyond first trimester of pregnancy doesn't prevent pre-eclampsia, revealed study published in The BMJ.
High Dose Folic Acid Does Not Prevent Pre-eclampsia in High Risk Women, Finds Study
High Dose Folic Acid Does Not Prevent Pre-eclampsia in High Risk Women, Finds Study

Pre-eclampsia is a serious condition where abnormally high blood pressure and other complications develop during pregnancy. It affects about 3-5% of pregnancies and is dangerous for both mother and child.

Previous observational studies have shown a potential protective effect, but findings have been inconsistent, and there is currently no clear guidance for the use of high dose folic acid to prevent pre-eclampsia in women with risk factors for the condition.

So an international research team decided to conduct a randomised trial - the Folic Acid Clinical Trial (FACT) - to evaluate the effect of high dose folic acid supplementation beyond the first trimester of pregnancy on the risk of developing pre-eclampsia among pregnant women already at high risk for this condition.

They included 2,301 pregnant women who were between 8 and 16 weeks' pregnant at the start of the study and had at least one risk factor for pre-eclampsia (existing high blood pressure, pre-pregnancy diabetes, twin pregnancy, pre-eclampsia in a previous pregnancy, or a body mass index of 35 or more).

Women were randomised to receive either daily high dose (4 mg) folic acid or placebo in addition to up to 1.1mg of folic acid throughout pregnancy.

Information on personal characteristics and medical history was recorded and participants had a total of four follow-up visits during the study period.

After taking account of factors that could have affected the results, they found that pre-eclampsia occurred in 169 out of 1,144 (14.8%) women in the folic acid group and 156 out of 1,157 (13.5%) in the placebo group. There was no evidence of differences between the groups for any other adverse outcomes.

And they suggest that "high dose recommendation should now cease, and the search for an effective and acceptable strategy to prevent pre-eclampsia must continue."

In a linked editorial, Professor Lucy Chappell and colleagues stress that the lack of benefit reported in this trial "must not detract in any way from the importance of folic acid supplements for the prevention of neural tube defects."

However, they say these findings "are another disappointment in the long search for a more effective measure to prevent pre-eclampsia" and they call for continued efforts towards a global reduction in pre-eclampsia related deaths.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

Recommended Reading

More News on:

Eclampsia Pre Eclampsia Pregnancy and Complications Myelomeningocele Cantaloupes - The Healthy Fruit HELLP Syndrome Top 10 Alarming Risks of Low Birthweight in Babies 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive