![Heavy Cannabis Users May Need Higher Dosage for Sedation Heavy Cannabis Users May Need Higher Dosage for Sedation](https://images.medindia.net/health-images/1200_1000/cannabis-smokers-at-high-risk-for-bone-fractures.jpg)
‘Heavy cannabis users may require a higher dosage for sedation during medical procedures.’
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"Some of the sedative medications have dose-dependent side effects, meaning the higher the dose, the greater the likelihood for problems," said lead researcher Mark Twardowski from Western Medical Associates in Colorado, US. Read More..
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"That becomes particularly dangerous when the suppressed respiratory function is a known side effect," Twardowski added.
For the study, the researchers in Colorado examined the medical records of 250 patients who received endoscopic procedures after 2012, when the state legalized recreational cannabis.
Patients who smoked or ingested cannabis on a daily or weekly basis required 14 percent more fentanyl, 20 percent more midazolam, and 220 percent more propofol to achieve optimum sedation for routine procedures, including colonoscopy, showed the findings.
"Cannabis has some metabolic effects we don't understand, and patients need to know that their cannabis use might make other medications less effective. We're seeing some problematic trends anecdotally, and there is virtually no formal data to provide a sense of scale or suggest any evidence-based protocols," Twardowski said.
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Source-IANS