About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Miniature Device Could Show Effectiveness of Cancer Drugs on Tumors

Font : A-A+

Miniature Device Could Show Effectiveness of Cancer Drugs on Tumors

Highlights

  • A miniature device has been developed to assess the effects of anti-cancer drugs.
  • The device could hasten the adoption of drugs that prove successful in anti-cancer treatments.
  • A miniature lab device that could speed up the adoption of new anti-cancer treatments has been developed by researchers at the University of Huddersfield.

    Cancer Breakthrough: Miniature Drug Device

Advertisement


The device is a small, versatile and simple-to-use microfluidic system. It consists of a series of chambers that allow researchers to monitor the response of hypoxic cells (deficient in oxygen and therefore resistant to therapy) when drugs are introduced.

The microfluidic device was developed by Professor Roger Phillips and Dr Simon Allison at the University of Huddersfield formed a collaboration with researchers in Spain - based at institutions that include the Aragon Institute of Biomedical Research.
Advertisement

Evaluation of Anti-Cancer Drugs in Microfludic Device

The device is made of glass which enables researchers to visualize the microenvironment and monitor the response of tumor cells to the anti-cancer drug.

The test cells grown in the lab can be spheroid. The 3D nature cells inside the microfluidic device allow the researchers to visualize what is happening to them internally while interacting with the drug, explained Professor Phillips, specialist in the evaluation of new anti-cancer drugs.

"We can see the drugs moving in, and see hypoxia developing in the center," said Professor Phillips. The microfluidic device could also be used for a wide range of other applications.

In the recent years, there have been major improvements in knowledge of cancer cell biology, but clinical approval of new drugs has not kept pace. Development of in vitro preclinical models that are better predictors of success in advanced preclinical and clinical testing could speed up the drug adoption process.

The researchers hope that the microfluidic device could help address the urgent need for new in vitro model to mimic the key aspects of the tumor microenvironment and therefore allow early assessment of the anti-cancer drugs, speeding up the adoption of those that are shown to be therapeutically effective.

Researchers have described the microfluidic device in Scientific Reports, from the publishers of leading journal Nature, titled "Development and characterization of a microfluidic model of the tumor microenvironment."

Anti-Cancer Drugs

Cancer is defined as the abnormal growth of cells with loss of differentiation and metastasis. Anti-cancer drugs are used to control the growth of tumor cells. Anti-cancer drugs are also known as Antineoplastic that prevents or inhibit the maturation and proliferation of neoplasms. There is a whole range of different anti-cancer drug treatment options. The latest anti-cancer drugs are called Biologics.

Reference:
  1. Jose M. Ayuso, María Virumbrales-Muñoz, Alodia Lacueva, Pilar M. Lanuza, Elisa Checa-Chavarria, Pablo Botella, Eduardo Fernández, Manuel Doblare, Simon J. Allison, Roger M. Phillips, Julián Pardo, Luis J. Fernandez & Ignacio Ochoa. 'Development and characterization of a microfluidic model of the tumour microenvironment'Scientific Reports 6, (2016) doi:10.1038/srep36086


Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Fermented Skin Care
Television Binge-Watching May Boost the Risk of Deadly Blood Clots
Western Diet may Augment the Risk of Autoimmune Diseases
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Drugs Banned in India Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment Non-Communicable Diseases 

Recommended Reading
In Treating Wet AMD, Cheaper Anti-cancer Drug Equally Effective as Expensive Drug
In treating the most common cause of blindness in older adults, an anti-cancer drug has been proven ...
Anti-Cancer Drug can Activate Hidden HIV: Study
HIV researchers from Aarhus University and Aarhus University Hospital in Denmark have shown that an ...
Berlusconi's New Venture: Anti-Cancer Drug Firm
Age-defying Italian Prime Minister Silvio Berlusconi has become the main shareholder of a company .....
Heart Dysfunction Caused by Powerful Anti-Cancer Drug may be Reduced by Dietary Inorganic Nitrate
Nutrient supplementation, like the kind that is found in leafy greens, spinach and lettuce, may ......
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Non-Communicable Diseases
Non-Communicable Diseases (NCDs) are a group of chronic non-infectious diseases which include Cardio...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)