About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Hole in the Heart Increases Risk for Stroke After Surgery
Advertisement

Hole in the Heart Increases Risk for Stroke After Surgery

Font : A-A+

Highlights:
  • Preoperatively diagnosed patent foramen ovale (PFO) is associated with perioperative ischemic stroke.
  • Patent foramen ovale (PFO) is the medical term for ‘hole in the heart’.
  • Looking for this hole before surgery may influence surgical decision-making as it contributes to stroke.

Post-surgery stroke caused by hole in the heart
A hole between the upper chambers of the heart that fails to close after birth doubles the risk of stroke within 30 days of non-cardiac surgery, recent research finds.

The research suggests the hole itself, known as a patent foramen ovale (PFO), contributes to the risk for stroke in patients following surgery. Stroke is a common complication after surgery.

Listen to this article
0:00/0:00
Advertisement

Hole in the Heart Increases Risk for Stroke After Surgery

Normally, the heart pumps blood through the right atrium and ventricle to the lung to pick up oxygen. The freshly oxygenated blood returns to the heart's left atrium and ventricle, from which it travels to the rest of the body. However, in one in five people (about 65 million Americans), a PFO allows blood from the right side of the heart to mix with blood in the left - bypassing the lung - and ultimately travel to the brain. If a clot is present, it too can reach the brain, causing stroke.

"We already knew that a PFO increases the risk of a second stroke in people who have previously had a stroke," said Matthias Eikermann, MD, Ph.D, of the Department of Anesthesiology at Beth Israel Deaconess Medical Center (BIDMC), who lead the current study. "Our laboratory is looking for ways to reduce complications after non-cardiac surgery so we investigated whether the presence of PFO increases stroke risk after surgery."
Advertisement

Strong association between patent foramen ovale (PFO) and stroke after surgery
To assess that risk, Eikermann and colleagues reviewed the case histories of more than 150,000 patients who underwent surgery at one of three New England hospitals from 2007-2015. Analysis revealed that approximately 3.2 percent of patients with a PFO had a stroke within 30 days after surgery, compared with 0.5 percent of patients without a PFO. Additionally, the authors found that PFO-related strokes were more neurologically severe than those in patients without a PFO.

"We were surprised about the high magnitude of the risk of stroke in patients with PFO after surgery - the patients we studied did not have any sign or symptom of stroke prior to surgery," said Eikermann. "The risk of stroke during the short observation period of 30 days after surgery in this analysis is even higher than the risk observed over several years in patients who have had a prior stroke not linked to surgery."

New findings offer preventive measures
The authors conclude that minimizing the risk posed by a PFO could substantially reduce the number of post-operative strokes. While it remains an open question and one not addressed in this study, the authors suggest that eliminating the PFO entirely prior to surgery or manipulating the coagulation system immediately after surgery deserve further study to decrease the risk of post-operative stroke.

"Stroke is a devastating post-surgical complication, and we have a new pathway with known treatments that potentially could be used to decrease the risk," said Eikermann who emphasized that most patients do not know that they have a PFO before surgery. "Future studies will be helpful to see if performing routine echocardiography prior to surgery changes our surgical decision-making by specifically looking for and diagnosing a PFO before it contributes to stroke."

References :
  1. Pauline Y. Ng, Andrew K. Ng et al. Association of Preoperatively Diagnosed Patent Foramen Ovale With Perioperative Ischemic Stroke, JAMA doi:10.1001/jama.2017.21899


Source: Eurekalert

Citations   close

Advertisement
Advertisement
Advertisement

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Hole in the Heart Increases Risk for Stroke After Surgery Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests