Highlights Wireless electroceutical dressing (WED) generates a weak electric field without any external power supply and can be used like any other disposable dressing. Bandages using WED disrupt bacterial bio-film infection which accounts for at least 75 percent of bacterial infections. The bandage also fights antibiotic resistance and enable healing in infected burn wounds. Special bandages using weak electric fields disrupt bacterial bio-film infection, combat antibiotic resistance and enable healing in infected burn wounds. The dressing becomes electrically active upon contact with bodily fluids. "Drug resistance in bacteria is a major threat, and antibiotic-resistant biofilm infections are estimated to account for at least 75 percent of bacterial infections in the United States," said Dr. Chandan Sen, director of Ohio State's Center for Regenerative Medicine & Cell Based Therapies. Electric Bandages Help Fight Antimicrobial Resistance in Burns This is the first pre-clinical long-term porcine study to recognize the potential of 'electroceuticals' as an effective platform technology to combat wound biofilm infection. ‘Electroceuticals - using mild current for disease treatment is an effective platform technology to combat wound biofilm infection.’ Biofilm Infection Bacterial biofilms represent a major wound complication. Resistance of biofilm towards drug interventions calls for alternative strategies. Bacteria rely on electrostatic interactions to adhere to surfaces, an important aspect of biofilm formation. The concept that weak electric fields may have anti-biofilm property was first reported in 1992. This study builds on Sen's 2014 research with a wireless electroceutical dressing (WED) using silver and zinc printed on fabric. When moistened, WED generates a weak electric field without any external power supply and can be used like any other disposable dressing. "The fact that wireless electric dressing is FDA-cleared and already in clinical use heightens the need to understand underlying mechanisms to enable optimal use," Sen said. "Since it relies on electrical principles, it's not subject to the mechanisms that may promote drug resistance. Understanding how this novel dressing may influence microbial, host and host-microbe interactions will determine the optimal use of this simple technology platform." During the study, WED dressing was applied within two hours of wound infection in pigs to test its ability to prevent biofilm formation. In addition, WED was applied after seven days of infection to study disruption of established biofilm. Wounds were treated with placebo dressing or WED twice a week for 56 days. Both proved successful, Sen said. During burn injury, barrier function of the skin is breached, leaving the body vulnerable. Patients with burn injuries risk dehydration, along with the potential of foreign agents such as bacteria and allergen entering into the body and causing potential health complications. "Our study shows that WED may be viewed as a first generation electroceutical wound care dressing, and it also accelerated functional wound closure by restoring skin barrier function," Sen said. "Both from bacterial biofilm structure as well as host response perspectives, WED was consistently effective. No batteries or wires are needed because we harness the power of electrochemistry" Reference Chandan Sen et al., Study shows electric bandages can fight biofilm infection, antimicrobial resistance. Annals of Surgery (2017). Source: Medindia << New Prevention Treatment for Hereditary Cancer Patients Chloroquine to Improve Drug Delivery to Tumors >> Recommended Reading Burns Burn injuries have reached epidemic proportions in recent years. Burn accident statistics show that at least 50% of all burn accidents can be prevented. READ MORE Vitamin D Levels Associated With Wound Healing in Burns Patients with higher levels of vitamin D have a better prognosis, with improved wound healing and reduced risk of infection. READ MORE Regulating Body Temperature in a Burns Patient Temperature regulating water-mattresses would aid in better body temperature regulation in burns patients than conventional methods, study suggests. READ MORE 3D Printing Restores Burnt Nose of Teenager The burnt nose of a teenager is restored using 3D printing technique, which is a boon for burn victims and people looking for nose jobs. READ MORE Food Preservatives - How Safe Are They? Food preservatives are basically antimicrobials or anti-oxidants that help preserve food by destroying the microbes and stopping decomposition of food products. READ MORE Most Popular on Medindia Accident and Trauma Care Pregnancy Confirmation Calculator Drug - Food Interactions More News on: BurnsFood Preservatives - How Safe Are They?