About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Does Insulin Resistance Deteriorate Brain Function?

Font : A-A+

Highlights
  • When the cells fail to respond to the hormone insulin due to fat surrounding the cells, it is called insulin resistance.
  • The resistance prevents muscle, fat, and liver cells from easily absorbing glucose and excess glucose is accumulated in the blood.
  • Apart from diabetes and certain hormone disturbances, insulin resistance is linked to cognitive impairment.

Does Insulin Resistance Deteriorate Brain Function?

Insulin resistance, caused in part by obesity and physical inactivity, is also linked to a more rapid decline in cognitive performance.

According to the study published in the Journal of Alzheimer's Disease, both diabetic and non-diabetic subjects with insulin resistance experienced accelerated cognitive decline in executive function and memory.

Advertisement


The study was led jointly by Prof. David Tanne and Prof. Uri Goldbourt and conducted by Dr. Miri Lutski, all of TAU's Sackler School of Medicine.

Insulin Resistance

Insulin resistance is a condition in which cells fail to respond normally to the hormone insulin. The resistance prevents muscle, fat, and liver cells from easily absorbing glucose. As a result, the body requires higher levels of insulin to usher glucose into its cells.
Advertisement

Without sufficient insulin, excess glucose builds up in the bloodstream, leading to prediabetes, diabetes, and other serious health disorders.

Twenty-year Follow up study

The scientists followed a group of nearly 500 patients with existing cardiovascular disease for more than two decades. They first assessed the patients' baseline insulin resistance using the homeostasis model assessment (HOMA), calculated using fasting blood glucose and fasting insulin levels.

Cognitive functions were assessed with a computerized battery of tests that examined memory, executive function, visual spatial processing, and attention. The follow-up assessments were conducted 15 years after the start of the study, then again five years after that.

The study found that individuals placed in the top quarter of the HOMA index, were at an increased risk for poor cognitive performance and accelerated cognitive decline, compared to those in the remaining three-quarters of the HOMA index. Adjusting for established cardiovascular risk factors and potentially confounding factors did not diminish these associations.

"These are exciting findings because they may help to identify a group of individuals at increased risk of cognitive decline and dementia in older age," says Prof. Tanne. "We know that insulin resistance can be prevented and treated by lifestyle changes and certain insulin-sensitizing drugs."

"This study lends support for more research to test the cognitive benefits of interventions such as exercise, diet, and medications that improve insulin resistance in order to prevent dementia," says Prof. Tanne. The team is currently studying the vascular and non-vascular mechanisms by which insulin resistance may affect cognition.

Reference
  1. David Tanne et al., Insulin Resistance and Future Cognitive Performance and Cognitive Decline in Elderly Patients with Cardiovascular Disease, Journal of Alzheimer's Disease (2017) http:dx.doi.org/10.3233/JAD-161016.


Source: Medindia

Citations   close

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Diabetes - Essentials Parkinsons Disease Surgical Treatment Insulin Delivery Devices Metabolic Syndrome Gestational diabetes Brain Brain Facts Type 2 Diabetes Diabetes - Foot Care 

Most Popular on Medindia

Calculate Ideal Weight for Infants A-Z Drug Brands in India The Essence of Yoga Pregnancy Confirmation Calculator Drug - Food Interactions Diaphragmatic Hernia Find a Doctor Accident and Trauma Care Post-Nasal Drip Color Blindness Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Does Insulin Resistance Deteriorate Brain Function? Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests