About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Can Taking Paracetamol During Pregnancy Inhibit Masculinity in the Infant?
Advertisement

Can Taking Paracetamol During Pregnancy Inhibit Masculinity in the Infant?

Font : A-A+

Highlights:
  • Paracetamol is a common drug that is used for relieving pain.
  • Scientists have found that taking paracetamol during pregnancy can inhibit the infant’s masculinity.
  • It is therefore important to deliberate before taking the medication, as it could increase the risk of malformation of the testicles in infants.

Paracetamol is a common drug used for relieving pain. However, during pregnancy it is important to think twice before taking the medication as it is capable of damaging the development of male behaviors, finds a new study from the University of Copenhagen.

Prior studies have found that the drug is capable of inhibiting the development of the male sex hormone testosterone in male fetuses. This could increase the risk of malformation of the testicles in infants.

Advertisement

Can Taking Paracetamol During Pregnancy Inhibit Masculinity in the Infant?

David Mobjerg Kristensen, researcher at the Department of Biomedical Sciences and the Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, said, that a reduced level of testosterone at the fetal stage could be significant for the behavior of adult males.

"We have demonstrated that a reduced level of testosterone means that male characteristics do not develop as they should. This also affects sex drive. In a trial, mice exposed to paracetamol at the fetal stage were simply unable to copulate in the same way as our control animals. Male programming had not been properly established during their fetal development and this could be seen long afterwards in their adult life. It is very worrying."
Advertisement

The administered dose to the mice was very close to the dose of the pregnant women. The clinical trials are restricted to mice and the results can be the same to the humans. But, the harmful effects of paracetamol could be improper to undertake the same trials on humans.

Reduced Masculinity
Testosterone is the male sex hormone that helps to develop the male body and male programming of the brain. The masculine behaviors involved aggressiveness, ability to mate and the need for territorial marking.

The mice reacted significantly and more passively than normal for all the three parameters. The mice did not attack other males, were unable to mate and behaved more like female mice when it came to urinary territorial marking.

The specific effects of the lack of testosterone on the brain were studied after observing the changed behavioral patterns.

"The area of the brain that controls sex drive - the sexual dimorphic nucleus - had half as many neurons in the mice that had received paracetamol as the control mice. The inhibition of testosterone also led to a halving of the activity in an area of the brain that is significant for male characteristics." explained David Mobjerg Kristensen.

Female Fertility Affected
The research study that focused on the effect of paracetamol on masculine characteristics. However, paracetamol during pregnancy can have the potential to influence the lives of female mice.

The research team published a study showing that the female mice could have fewer eggs in their ovaries when the mothers had taken paracetamol during pregnancy. Even though paracetamol is harmful, it is not compulsory that it should never be taken during pregnancy.

David Mobjerg Kristensen, said, "I personally think that people should think carefully before taking medicine. These days it has become so common to take paracetamol that we forget it is a medicine And all medicine has side effects. If you are ill, you should naturally take the medicine you need. After all, having a sick mother is more harmful for the fetus."

The author finally concluded that pregnant women must continue to follow the guidelines that are given by the country's health authorities and could recommend people to contact their General Physician, if there is any doubt about the use of paracetamol.

References
  1. Anders Hay-Schmidt, Olivia T Ejlstrup Finkielman, Benjamin A H Jensen, Christine F Høgsbro, Jacob Bak Holm, Kristoffer Haurum Johansen, Tina Kold Jensen, Anderson Martino Andrade, Shanna H Swan, Carl-Gustaf Bornehag, Søren Brunak, Bernard Jegou, Karsten Kristiansen, David Møbjerg Kristensen. Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs masculinisation of male brain and behavior. Reproduction, 2017; 154 (2): 145 DOI: 10.1530/REP-17-0165


Source: Medindia

Citations   close

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Get Involved and Stand Up for Human Rights on Human Rights Day 2022
Coronary Artery Bypass Grafting
Macronutrients Calculator for Weight Loss
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Trimester of pregnancy Pregnancy and Exercise Home Pregnancy Test Pregnancy Psychological Changes In Pregnancy Drugs in Pregnancy and Lactation Breech Presentation and Delivery Air travel: To fly or not to fly Pregnancy and Antenatal Care AIDS and Pregnancy 

Most Popular on Medindia

Blood Pressure Calculator Sanatogen How to Reduce School Bag Weight - Simple Tips Drug Side Effects Calculator Accident and Trauma Care Drug Interaction Checker Indian Medical Journals Blood Donation - Recipients Diaphragmatic Hernia Sinopril (2mg) (Lacidipine)
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Can Taking Paracetamol During Pregnancy Inhibit Masculinity in the Infant? Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests