- Alzheimer's disease is a
neurological disorder which leads to memory loss, confusions and reduced
- New experimental NTRX-07 drug shows
promise in treating Alzheimer's disease.
- The drug restores
cognitive skills, removes abnormal protein clumps and decreases brain
A research team from
Cleveland Clinic Lerner College of Medicine has identified a new drug with
potential memory restoring abilities in Alzheimer's patients. The new
experimental drug 'NTRX -07 ' for the treatment of neuropathic pain (chronic
pain that occurs along with tissue injury) was found to prevent inflammation
and remove abnormal protein clumps in the brain.
The research study was
presented at the Anesthesiology 2016 annual meeting this month.
‘New drug shows potential memory restoring abilities in Alzheimer’s patients.’
usually starts with a mild memory loss and
gradually affects the day to day activities of a person's life.
is the most common form of Alzheimer's disease and almost 4 million people in India suffer due to
some form of dementia
According to the Centers
for Disease Control and Prevention, around 14 million people in America are
estimated to be affected with Alzheimer's disease by 2050
Research Study on 'NTRX
-07 ' Drug
A team of researchers
from Cleveland Clinic Lerner College of Medicine tested the effects of the new
drug 'NTRX -07 ' on mice bred with neurodegenerative diseases like Alzheimer's.
Inflammation in the
brain usually occurs due to the presence of twisted bundle fibers and
development of abnormal protein clumps called amyloid plaques
plaques accumulate in the immune cells (microglia) which in turn damage the
nerve cells and cause decreased cognitive ability.
Mohamed Naguib, M.D., a
physician anesthesiologist in the Department of General Anesthesiology at the
Cleveland Clinic and professor of anesthesiology at the Cleveland Clinic Lerner
College of Medicine said that "This drug may reduce inflammation in the brain,
which is linked to Alzheimer's disease".
abilities of the drug was studied when researchers tried to use the drug for
chronic pain conditions called neuropathic pain.
Dr.Naguib said, Patients
who have neuropathic pain, have chronic neuro-inflammation and NTRX-07 drug
helps blunt the inflammation.
Mechanism of Action
The author said "NTRX-07
uses a different mechanism than many other Alzheimer's drugs currently
available, as it targets the cause of the disease, not just the symptoms."
Immune cells of the mice
have CB2 receptors on the surface which is capable of producing
anti-inflammatory response when activated. The drug was found to act by
targeting the CB2 receptors which prevent inflammation and brain tissue damage.
NTRX-07 drug was found
to improve cognitive skills and remove abnormal amyloid plaques
. It also
increased the SOX2 protein levels
which help to develop new brain cells
and protect the brain in Alzheimer's patients when compared to a placebo drug
which in contrast decreases the protein levels, causes active inflammation and
poor cognitive skills.
The drug will be
developed by NeuroTherapic TM company founded by Dr. Naguib and Joseph F. Foss,
M.D., director of Clinical Research for General Anesthesiology, Cleveland
Clinic. The company has also received sponsors from various Alzheimer's
association to initiate human clinical studies for the drug by 2017.
Interesting Facts on Alzheimer's Disease
Drugs Used For the
Treatment of Alzheimer's Disease
- Alzheimer's disease is named
after Dr. Alois Alzheimer who noticed abnormal clumps in the brain tissue
of a woman who died due to mental illness.
- Symptoms of Alzheimer's
disease usually occur after the age of 60. Younger people are less
common to be affected with the disease.
- 1 in 3 seniors
found to die due to Alzheimer's disease.
- There is no
single specific test to diagnose Alzheimer's disease.
of high cholesterol and saturated fats may increase the risk of Alzheimer's
Some of the commonly
used drugs for the treatment of Alzheimer's disease include:
These drugs help to mask
the symptoms of the disease by inhibiting the specific action of the
neurotransmitters in the brain.
Side effects associated
with these drugs include
Drug Shows Promise in Treating Alzheimer's Disease - (http://newswise.com/articles/experimental-drug-shows-promise-in-treating-alzheimer-s-disease)
- Alzheimer's Disease Fact Sheet - (https://www.nia.nih.gov/alzheimers/publication/alzheimers-disease-fact-sheet)
- What Is Alzheimer's? - (http://www.alz.org/alzheimers_disease_what_is_alzheimers.asp)
- Alzheimer's and Dementia in India -
- Current Alzheimer's Treatments - (http://www.alz.org/research/science/alzheimers_disease_treatments.asp)
- Facts About Alzheimer's Disease -