The child who received the first
successful double hand transplant is also the first child in whom a
research team has identified brain reorganization.
The brain remapping that was
caused due to amputation of the limbs has reverted back to the typical
pattern after transplantation.
Study shows new insights into
brain reorganization and brain plasticity in children.
Zion, a 10 year old, who underwent the first successful double hand
transplant also happens to be the first child in whom brain reorganization was
observed. While Zion had massive reorganization after his
limbs were amputated, the team has found that after transplantation his brain
remapping has started reverting to its normal pattern. This has brought back
function into Zion's newly transplanted hands. The study was conducted by
research teams from the Children's Hospital of Philadelphia and the Perelman School of Medicine at
the University of Pennsylvania and published in the Annals of Clinical
and Translational Neurology.
Harvey was born a normal child with hands and legs. But when he was two, an
unfortunate sepsis required the amputation of both his upper and lower limbs.
He had also received a kidney transplant at the age of 4, following
kidney failure. In 2015, 10 year old Zion was the world's first successful
double hand transplant recipient.
Brain Remapping Reversible In A 10-Year Old Recipient Of A Double Hand Transplant
Each area of the body that receives a sensory
input like the hands, feet, or
lips has a specific
location in the brain that
perceives the corresponding
sensory input that they send
back. This is called the somatosensory
representation where a particular
area of the brain reflects a part
of the body. However, when any part of the body stops receiving the input due
to reasons like amputations where the specific part is detached from the body,
the brain remaps itself. The brain remapping that occurs after
amputation of the upper limb is called massive cortical
‘Brain remapping that started almost 6 years back when Zion lost his limbs to amputation reverted back to a normal pattern following hand transplantation.’
"We know from
research in nonhuman primates and from brain imaging studies in adult patients
that, following amputation, the brain remaps itself when it no longer receives
input from the hands," said William Gaetz, PhD, first author from the
Biomagnetic Imaging Laboratory at Children's Hospital of Philadelphia.
"The brain area representing sensations from the lips shifts as much as 2
centimeters to the area formerly representing the hands."
the team that worked with Zion believe that his brain reorganization started 6
years before he received the transplant, the highlight was that, following
amputation the reorganization started to revert back to
normal somatosensory network.
(MEG) was used to measure magnetic activity in Zion's brain and in specific, to
detect the location of the brain, signal strength and timing of Zion's response
to sensory stimuli. The MEG's were conducted four times in the year after the
transplant. The same was also done on five healthy control children of the same
finger tips did not respond to touch during the first two visits. Also, when
his lips were touched, the MEG signal was found in the hand area of the brain's
cortex instead of the lip area. Moreover there was a 20 millisecond delay
compared to the healthy controls. During the last two visits, when fingertips
were stimulated MEG signals appeared in the hand region of the brain. Also, MEG
signals from lip stimulation had returned to the lip region of the brain with a
normal response time. Zion's brain that had
remapped after amputation was slowly beginning to revert to normal as his new
hands were receiving sensory input.
This is what L.
Scott Levin, MD, FACS, chairman of Orthopedic Surgery and a professor of
Plastic Surgery at Penn Medicine, and director of the Hand Transplantation
Program at CHOP, who lead the 40 member team that operated on Zion had to say:
changes observed in his brain, which our collaborative team has been closely
evaluating since his transplant two years ago, Zion is now the first
child to exhibit brain mapping reorientation. This is a
tremendous milestone not only for our team and our research, but for Zion
himself. It is yet another marker of his amazing progress, and continued
advancement with his new limbs."
W. Gaetz, et al, "Massive cortical reorganization following bilateral transplants of the hands: evidence from the first successful bilateral pediatric hand transplant patient," Annals of Clinical and Translational Neurology, Dec. 6, 2017.
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