Higher levels of certain bacteria found in the digestive tract increase the risk of certain health and disease outcomes. The gut bacteria and other microorganisms are linked to conditions like high blood pressure, high blood lipids, and body mass index (BMI).
‘The microbiota and the substances they produce are responsible for many diseases and health conditions. The gut microbiota might have an important role in maintaining health and could help in the development of novel treatments.’
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The human gut microbiome is the totality of microorganisms (generally bacteria and single-celled organisms called archaea) and their collective genetic material present in the digestive tract. Small-scale studies have suggested a link between the gut microbiome and individual diseases.Read More..
This study, for the first time, investigated multiple diseases and other traits in one cohort - revealing the staggering extent to which the microbiome influences sickness and health. The analysis used genetic data as a proxy for microbiome composition.
Study author Dr. Hilde Groot of University Medical Centre Groningen, the Netherlands. Explained, "Previous research has shown that the human gut microbiome composition could be partially explained by genetic variants. So, instead of directly measuring the make-up of the microbiome, we used genetic alterations to estimate its composition."
The study included 422,417 unrelated individuals in the UK Biobank who had undergone genotyping to identify their genetic make-up. Information was also collected on a wide range of diseases and other characteristics including BMI and blood pressure. The average age of participants was 57 years and 54% were women.
The researchers found that higher levels of eleven bacteria (estimated from genetic data) were associated with a total of 28 health and disease outcomes. These included chronic obstructive pulmonary disease (COPD), atopy (a genetic tendency to develop allergic diseases like asthma and eczema), frequency of alcohol intake, high blood pressure, high blood lipids, and BMI.
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Regarding alcohol consumption, Dr. Groot said, "What we eat and drink is connected to microbiome content, so we studied the links with meat, caffeine, and alcohol. We observed a relationship between raised levels of Methanobacterium and drinking alcohol more often. It is important to stress that this is an association, not a causal relation, and more research is needed."
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She concluded, "Follow-up studies are required to study causality before giving concrete advice to the public and health professionals. This study provides clues where to go."
ource-Eurekalert