About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Genetic Variants Linked With Severe Skin Reactions to Antiepileptic Drug Discovered

by Sheela Philomena on August 6, 2014 at 1:51 PM
Font : A-A+

 Genetic Variants Linked With Severe Skin Reactions to Antiepileptic Drug Discovered

Genetic variants that are linked with severe adverse skin reactions to the antiepileptic drug phenytoin have been identified by researchers. The results of the study are published in JAMA .

Phenytoin is a widely prescribed antiepileptic drug and remains the most frequently used first-line antiepileptic drug in hospitalized patients. Although effective for treating neurological diseases, phenytoin can cause cutaneous (skin) adverse reactions ranging from mild to severe. The pharmacogenomic basis of phenytoin-related severe cutaneous adverse reactions has not been known, according to background information in the article.

Advertisement

Wen-Hung Chung, M.D., Ph.D., of Chang Gung Memorial Hospital, Keelung, Taiwan, and colleagues investigated the genetic factors associated with phenytoin-related severe cutaneous adverse reactions. The case-control study was conducted in 2002-2014 among 105 cases with phenytoin-related severe cutaneous adverse reactions (n=61 Stevens-Johnson syndrome/toxic epidermal necrolysis and n=44 drug reactions with eosinophilia and systemic symptoms), 78 cases with maculopapular exanthema (a less severe type of rash), 130 phenytoin-tolerant control participants, and 3,655 population controls from Taiwan, Japan, and Malaysia. A genome-wide association study (GWAS) was conducted using the samples from Taiwan. The initial GWAS included samples of 60 cases with phenytoin-related severe cutaneous adverse reactions and 412 population controls from Taiwan.

Analysis of the data indicated that variants of the gene CYP2C, including CYP2C9*3, were associated with phenytoin-related severe cutaneous adverse reactions. The statistically significant association between CYP2C9*3, known to reduce drug clearance (the elimination of a drug from the body), and phenytoin-related severe cutaneous adverse reactions was replicated by the samples from Taiwan, Japan, and Malaysia, with a meta-analysis showing an 11 times higher odds of experiencing this reaction with this variant. Delayed clearance of plasma phenytoin was detected in patients with severe cutaneous adverse reactions, especially CYP2C9*3 carriers, providing a clinical link of the associated variants to the disease.
Advertisement

Delayed clearance was also noted in patients with severe cutaneous adverse reactions without CYP2C9*3, suggesting that nongenetic factors such as renal insufficiency, hepatic dysfunction, and concurrent use of substances that compete or inhibit the enzymes may also affect phenytoin metabolism and contribute to severe cutaneous adverse reactions.

"This study identified CYP2C variants, including CYP2C9*3, known to reduce drug clearance, as important genetic factors associated with phenytoin-related severe cutaneous adverse reactions. These findings may have potential to improve the safety profile of phenytoin in clinical practice and offer the possibility of prospective testing for preventing phenytoin-related severe cutaneous adverse reactions. More research is required to replicate the genetic association in different populations and to determine the test characteristics and clinical utility," the authors conclude.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
First-Ever Successful Pig-To-Human Kidney Transplantation
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Boils / Skin Abscess Genetics and Stem Cells Signature Drug Toxicity Pityriasis rosea Pemphigus Hives Scleroderma Vitiligo Skin Self Examination 

Recommended Reading
Adverse Drug Reaction and Toxicity Finder
Drugs can cause side effects and toxic reactions. These reactions can be very characteristic for ....
Allergy - Symptom Evaluation
An allergic reaction may be mild or severe. It usually involves the skin, respiratory system, ......
Alcohol Addiction to be Controlled by Anti-Epileptic Drug
Topiramate, an anticonvulsant medication, may help treat drinkers who aim to curb alcohol ......
Anti-epileptic Drugs Trigger Fracture Risk
People on anti-epileptic drugs are up to four times more likely to suffer spine, collar bone and ......
Boils / Skin Abscess
Encyclopedia section of medindia gives general info about Boils / Skin Abscess ...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Hives
Hives or Urticaria are allergic skin reaction that appear suddenly in clusters or as single bumps on...
Pemphigus
Pemphigus is a rare group of autoimmune diseases that affect the skin and mucous membranes causing b...
Pityriasis Rosea
Pityriasis rosea is a common skin disease that is not contagious. It manifests as oval-shaped, pink ...
Scleroderma
Scleroderma or CREST syndrome is a chronic, auto immune disease which manifests as thick, dry, fibro...
Skin Self Examination
The skin self examination means checking one’s own skin for any visible abnormal growths or unusual ...
Vitiligo
Vitiligo is a skin disease characterized by patches of unpigmented skin. Vitiligo is usually slowly ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use