Genetic Mutation : The Reason For Flat-Faced Dog Breeds

In pugs and bulldogs, it was found that the dog DNA has been linked to genetic mutation and hence, the reason for flattened face, reveals a new study.

Wondering why pugs and bulldogs have those flat-faced shapes? Well, it was found that the dog DNA has linked a genetic mutation, which helps in detecting birth defects that affects babies’ head development in the womb, reveals a recent study. //

The results suggested that one variation found to disrupt the activity of a gene called SMOC2 is strongly linked to the length of the dog’s face. Animals with the mutation had significantly flatter faces, a condition called brachycephaly.

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‘Brachycephaly is a condition, where the shape of the skull is smaller than the normal size and is mostly flattened.’

The research reveals new insights into the genes that underpin skull formation in people and animals. Lead researcher Jeffrey Schoenebeck said that the results shed light on the molecular nature of this type of skull form that is so common and popular among dogs.

Researchers at the University of Edinburgh’s Roslin Institute analysed DNA samples from 374 pet dogs of various pedigree and mixed breeds. The dogs were being treated at the Royal (Dick) School of Veterinary Studies.

All of the animals underwent body scans as part of their care, producing detailed three-dimensional images of the dogs’ heads. These high-resolution images called CT scans enabled the researchers to take precise measurements of the shape of the dog’s skull.

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By comparing the dogs’ genetic information with measurements of their skulls, the team was able to pinpoint DNA variations that are associated with different head shapes.

The results suggested that one variation found to disrupt the activity of a gene called SMOC2 was strongly linked to the length of the dog’s face. Animals with the mutation had significantly flatter faces, a condition called brachycephaly.

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Babies are sometimes born with brachycephaly too, though little is known about its causes. The scientists further suggested that screening children for changes in the SMOC2 gene could help to diagnose the condition. The study is published in the Journal Current Biology.

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Source-ANI