Mosquitoes that carry a specific chromosomal rearrangement in their genes are more likely to feed on cattle than on humans. Thus, the odds of transmitting the malaria parasite in reduced, finds a new study.
The parasite causing the disease is carried by Anopheles mosquitoes species that transmit it to humans by biting them. One of these species is Anopheles arabiensis, which is the primary vector of malaria in East African countries.
Rates of malaria transmission depends on whether mosquitoes bite humans. When mosquitoes bite cattle, malaria does not spread because these animals are dead-end hosts.
Using a population genomics approach, the study established an association between human feeding and a specific chromosomal rearrangement in the major east African malaria vector.
"Whether there is a genetic basis to feeding preferences in mosquitoes has long been debated. This work paves the way for identifying specific genes that affect this critically important trait," said Bradley Main, researcher at the University of California - Davis, in the US.
In the study, the team sequenced the genomes of 23 human-fed and 25 cattle-fed mosquitoes collected indoors and outdoors from the Kilobero Valley in Tanzania.
An analysis of these genomes allowed them to identify a chromosomal rearrangement -- known as the 3Ra inversion -- associated with cattle feeding.
It however did not appear to have an impact on the mosquitoes' resting behaviors.
Using genetics to better understand and track mosquito behaviour can improve local control strategies.
This knowledge may also open novel avenues for stopping malaria's spread, such as genetically modifying mosquitoes to prefer cattle over people, the researchers noted, in the paper published in the journal PLOS Genetics.