About My Health Careers Internship MedBlogs Contact us

Gene Donors at High Cancer Risk Received Feedback: Study

by Iswarya on November 27, 2020 at 11:56 AM
Font : A-A+

Gene Donors at High Cancer Risk Received Feedback: Study

New study analyzed how people at high risk for breast, ovarian, or prostate cancer respond to genetic findings' feedback. Gene donors who chose to get results appreciated being contacted and considered the information given to be valuable, reports a new study. The findings of the study are published in the European Journal of Human Genetics.

Authors find that knowing more about people's genetic traits will significantly expand the chances of early detection of breast-, ovarian- and prostate cancer in the future.


The national breast cancer screening program in Estonia and in many other countries targets women in a limited age group (50-69 years). However, it's been known for quite some time that a smaller proportion of breast, ovarian, or prostate cancer can be caused by high-risk genetic variants genes, and then cancer often occurs at a younger age. Therefore, the medical system consistently misses people with a hereditary predisposition. If scientists succeed in translating large-scale genomic research into clinical practice, healthcare could improve markedly and enable healthcare providers to personalize prevention plans and treatments.

"In this case, we applied the genotype-first method. In other words, we contacted biobank participants with specific findings in their BRCA1 and two genes, therefore being at higher risk for breast, ovarian, or prostate cancer. In contrast to the approach of the current personal or family history-based clinical approach, we selected participants according to their genetic variants. We started with biobank participants and then included their family members," explained Marili Plover, one of the authors of the paper and a biomedical specialist.

According to the authors' results, all study participants considered the information provided to be understandable, interesting, and valuable. Researchers recommend the return of results in population-based biobanks. Although receiving genetic information may, in theory, cause difficult emotions, this study proved otherwise - even six months later, people reported that they were coping with the information received and had no regret regarding their decision to receive it.

Authors believe that this method could be viewed as a model for population-wide genetic testing. It helps to identify people at risk who would otherwise be unnoticed by the medical system based on personal and family histories only. Plover added that identifying people at risk before symptoms mean individual surveillance and risk-reducing plan, therefore better survival rate and preparedness when symptoms arrive.

"Unfortunately, only 55% of the invites received responses, and we do not know the reasons for not responding to our invitation letter," said Plover. Authors discussed that it could be that some were fearful of receiving results, but it could also be that some did not understand that they could get valuable information as part of this study, and additionally, non-responders could have had more practical reasons such as not receiving the letter, or being unable to attend the face-to-face counseling sessions held in Tartu. "Therefore, we are really grateful to those of the biobank participants and their relatives who joined the study," added Plover.

Source: Eurekalert

News A-Z
News Category
What's New on Medindia
Black Tea Protects against Blood Pressure and Heart Diseases
Green Mediterranean Diet may Help Repair Age-Related Brain Damages
Cervical Cancer Awareness Month 2022
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
DNA Finger Printing Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Weaver Syndrome Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant Immune Checkpoint Inhibitors for Cancer Treatment Non-Communicable Diseases 

Recommended Reading
Breast Cancer Management: Advances
The crab that invades the breast is no more a fear factor with all the advancements that medical ......
Screening for Breast Cancer with Clinical Breast Examination
Clinical breast examination is a simple and inexpensive method of detecting breast cancer ......
Triple-Negative Breast Cancer
Triple-negative breast cancers are ER negative, PR negative, and lack overexpression of HER-2. They ...
Breast Cancer
Breast cancer is a cancer that affects the breasts or mammary glands. Early detection and lifestyle ...
Common Lifestyle Habits that Cause Diseases
Cigarette smoking, unhealthy diets, overuse of alcohol, and physical inactivity are some of the most...
DNA Finger Printing
DNA fingerprinting is a technique which helps forensic scientists and legal experts solve crimes, id...
Health Benefits of Dandelion Plant
What is dandelion? Dandelion greens are nutrition powerhouses with a wide range of health benefits. ...
Immune Checkpoint Inhibitors for Cancer Treatment
Immune checkpoint inhibitors are promising drugs to treat a variety of cancers and the FDA has appro...
Non-Communicable Diseases
Non-Communicable Diseases (NCDs) are a group of chronic non-infectious diseases which include Cardio...
Tattoos A Body Art
Tattoos are a rage among college students who sport it for the ‘cool dude’ or ‘cool babe’ look...
Weaver Syndrome
Weaver syndrome is a genetic disorder in which children show accelerated bone growth, advanced bone ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)