Stomach ulcers and cancer are promoted by a bacterium known as Helicobacter pylori, but how the bacterium initially interacts and irritates gastric tissue is not well understood. An article published on July 17th in PLOS Pathogens now describes that H. pylori rapidly identifies and colonizes sites of minor injuries in the stomach, almost immediately interferes with healing at those injury sites, and so promotes sustained gastric damage.
Smoking, alcohol, excessive salt intake, and non-steroidal anti-inflammatory drugs cause damage to the tissue lining the stomach, and are associated with stomach ulcers. A team of scientists led by Marshall Montrose, from the University of Cincinnati, USA, asked whether H. pylori can sense and respond to such damage and so contribute to disease development.
The researchers induced small stomach lesions in anesthetized mice and observed that H. pylori bacteria can rapidly detect the injury site and navigate toward it. Within minutes, accumulation of bacteria interferes with repair of the tissue damageand these results are the earliest indication showing H. pylori causing disease.
While the signals that attract H. pylori (but not benign stomach bacteria) toward injured tissue are not yet known, the researchers hope that their ability to rapidly measure H. pylori accumulation at the injured site now provides an experimental set-up to determine the factor(s) involved.
"The broader implications of our work", the researchers say, "are that even subclinical insults to the stomach that occur in daily life (damage from grinding of food, ingestion of alcohol, taking an aspirin) can potentially attract H. pylori and not only slow repair of any existing damage, but maybe also provide an initiation site that can start the pathogenic sequence of more severe stomach diseases caused by H. pylori".