Scientists have added 4 new genes to the growing list of those known to cause increased breast cancer risk when mutated.

Tavtigian said originally, the gene we are currently studying, called RINT1, was not considered a human cancer susceptibility gene. But then we discovered there was a two- to three-fold increase in risk for breast cancer in families that carry a mutation in that gene.
Surprisingly, RINT1 was also found to increase risk for a broad spectrum of gastrointestinal and gynecological cancers in these families.
In another study led by Tavtigian, mutations in three other genes-MRE11A, RAD50, and NBN-were also confirmed to increase breast cancer risk, as reported in the journal Breast Cancer Research June 3.
The findings have been published in the journal Cancer Discovery.
Source-ANI