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Food Addiction May Have Its Roots in Neural Activity

by Tanya Thomas on April 6, 2011 at 9:28 AM
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 Food Addiction May Have Its Roots in Neural Activity

A new study has found that people with an addictive-like eating behaviour have greater neural activity in certain regions of the brain similar to substance dependence, including elevated activation in reward circuitry in response to food cues.

"Based on numerous parallels in neural functioning associated with substance dependence and obesity, theorists have proposed that addictive processes may be involved in the etiology of obesity. Food and drug use both result in dopamine release in mesolimbic regions [of the brain] and the degree of release correlates with subjective reward from both food and drug use.


"The researchers add that to their knowledge, no studies have examined the neural correlates of addictive-like eating behavior," said authors.

Ashley N. Gearhardt, of Yale University, New Haven, Conn., and colleagues examined the relation between food addiction (FA) symptoms, as assessed by the Yale Food Addiction Scale (YFAS), with neural activation (measured via functional magnetic resonance imaging) in response to cues signaling impending delivery of a highly palatable food (chocolate milkshake) vs. a tasteless control solution; and consumption of a chocolate milkshake vs. a tasteless solution. The study included 48 healthy young women ranging from lean to obese recruited for a healthy weight maintenance trial.

The researchers found that food addiction scores correlated with greater activation in areas of the brain including the anterior cingulate cortex (ACC), medial orbitofrontal cortex (OFC), and amygdala in response to anticipated receipt of food. Participants with high vs. low FA demonstrated greater activation in the dorsolateral prefrontal cortex and caudate during anticipated palatable food intake and reduced activation in the lateral OFC during palatable food consumption.

"As predicted, elevated FA scores were associated with greater activation of regions that play a role in encoding the motivational value of stimuli in response to food cues. The ACC and medial OFC have both been implicated in motivation to feed and to consume drugs among individuals with substance dependence," said authors.

"In sum, these findings support the theory that compulsive food consumption may be driven in part by an enhanced anticipation of the rewarding properties of food. Similarly, addicted individuals are more likely to be physiologically, psychologically, and behaviorally reactive to substance-related cues."

The study will be published in the August print issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

Source: ANI

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