About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

First Measurement Standard for Breast Cancer MRI

by Julia Samuel on March 24, 2016 at 2:45 PM
Font : A-A+

First Measurement Standard for Breast Cancer MRI

A method used to identify and monitor breast cancer has now been developed.

Researchers at the National Institute of Standards and Technology (NIST) have developed an instrument -- a "phantom" -- to standardize MRIs of breast tissue and ensure quality control in comparing images within and between medical research studies.

Advertisement


Phantoms mimic the response of human tissue to help test the performance of medical imaging systems. NIST's new breast phantom also can be used to compare MRI scanners and train operators. The phantom supports quantitative MRI, which is increasingly used for breast cancer diagnosis, staging and treatment monitoring as well as for imaging other parts of the body.

NIST's prototype breast phantom was tested on MRI systems from two manufacturers in three configurations and produced accurate, quantitative images that could be used to evaluate common imaging procedures. Co-authors of the paper work at the University of California San Francisco where the phantom is already used in clinical trials.
Advertisement

The NIST phantom is widely useful because it fits most major MRI scanner designs and meets a full range of common clinical imaging needs. In addition, like NIST's other MRI phantoms, the breast phantom generates image data that can be traced to international measurement standards. Older breast phantoms don't offer all these capabilities.

The biggest design challenge was to create a lifelike mimic of both fat and fibroglandular tissue, NIST project leader Katy Keenan says. The design success led to industry's rapid commercialization of the phantom, currently used by five research groups.

"I believe the NIST phantom can have a big impact, especially because we are seeing more use of quantitative MRI for breast cancer," Keenan says. "It will be used by both researchers developing new techniques and by radiologists using techniques in the clinic."

The phantom has a flexible, modular design. The soft silicone shell (15 by 12.5 centimeters) enables fitting to different MRI scanners. Internal components are made of rigid polycarbonate to ensure regular geometry. The phantom has two basic types of internal arrangements, which can be paired for MRI scans.

One unit is designed for conventional MRI scans based on magnetic properties of hydrogen atoms. This unit contains four layers of small plastic spheres filled with tissue mimics -- corn syrup in water to represent fibroglandular tissue and grapeseed oil to represent fat. The spheres can be customized to meet special clinical needs. Potential future options include solutions that would mimic either benign cysts or tiny bits of calcium called microcalcifications, which can signal cancer.

The second phantom unit is designed for the newer technique of diffusion MRI, which measures the motion of water molecules within the breast. This unit contains plastic tubes filled with varying concentrations of a nontoxic polymer (polyvinylpyrrolidone), similar to NIST's diffusion MRI phantom. The solutions are tuned to mimic the differing diffusion properties of malignant tumors versus benign tumors.

Researchers continue to work on the NIST breast phantom. For instance, natural oils such as grapeseed oil can vary in consistency, so a different fat tissue mimic has been developed, a synthetic oil that remains stable across production batches and over time. In addition, a multi-site trial is planned to examine measurement variations at clinical imaging centers.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Women and Cancer Breast Biopsy Pagets disease of the breast Mastitis Cancer and Homeopathy Breast Cancer Facts Cancer Facts Cancer Tattoos A Body Art Breasts - Structures and Types 

Most Popular on Medindia

Find a Doctor Drug Side Effects Calculator A-Z Drug Brands in India Drug - Food Interactions Vent Forte (Theophylline) Blood Donation - Recipients Sanatogen The Essence of Yoga How to Reduce School Bag Weight - Simple Tips Calculate Ideal Weight for Infants
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

First Measurement Standard for Breast Cancer MRI Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests