Association between a family history of diabetes and increased bone mineral density is related to high insulin levels because insulin has a bone-building effect in postmenopausal women. These women are also at risk for diabetes, linked to skeletal fragility.
The association between type 2 diabetes and increased fracture risk is well documented. However, little was known about the possible effect of family history of diabetes on bone mineral density (BMD). A study from China now confirms that a history of first-degree family members with diabetes is linked to increased BMD as well as to insulin resistance. Results are published online in Menopause, the journal of The North American Menopause Society (NAMS).
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‘Understanding the early pathophysiology of altered bone mineral density is crucial in the prevention of diabetic osteoporosis’
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Because patients with type 2 diabetes are at an increased risk of fracture, understanding the early pathophysiology of altered BMD could be critical in the development of preventive strategies for diabetic osteoporosis. Although strong evidence has revealed normal to high BMD in most patients with type 2 diabetes, no data have been published, to date, that demonstrate whether BMD is altered in persons with a first-degree family history of diabetes.
In this new study involving nearly 900 normoglycemic postmenopausal women, it was found that the BMD of the lumbar spine and femoral neck was significantly higher in participants with a first-degree family history of diabetes than in those without such history, even in women with normal blood glucose levels. These same participants additionally showed increased insulin resistance and hyperinsulinemia.
![Osteopenia (Decreased Bone Density)]( "Osteopenia (Decreased Bone Density)")
Osteopenia refers to less bone density in bones. If it is not taken care of, then it can result in osteoporosis. Treatment includes exercises, lifestyle changes.
Findings were published in the article "Association of bone mineral density with a first-degree family history of diabetes in normoglycemic postmenopausal women."
"This study shows an association between a family history of diabetes and increased bone density in postmenopausal women. This finding may be related to higher insulin levels in these women with a hereditary predisposition to diabetes, because insulin has a bone-building effect. Although this sounds like good news, these women are at increased risk for developing diabetes, which is associated with skeletal fragility and increased fracture risk," says Dr. Stephanie Faubion, NAMS medical director.
Source: Eurekalert
Osteopenia (Decreased Bone Density)
Osteopenia refers to less bone density in bones. If it is not taken care of, then it can result in osteoporosis. Treatment includes exercises, lifestyle changes.
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Findings were published in the article "Association of bone mineral density with a first-degree family history of diabetes in normoglycemic postmenopausal women."
"This study shows an association between a family history of diabetes and increased bone density in postmenopausal women. This finding may be related to higher insulin levels in these women with a hereditary predisposition to diabetes, because insulin has a bone-building effect. Although this sounds like good news, these women are at increased risk for developing diabetes, which is associated with skeletal fragility and increased fracture risk," says Dr. Stephanie Faubion, NAMS medical director.
Source: Eurekalert
Osteoporosis
Osteoporosis is a bone disease that leads to an increased risk of fractures. The bone mass is reduced and the bones are porous, thereby resulting in weakness of the skeletal system of the body.
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 Type 2 DiabetesGlobalization and changing lifestyles has made diabetes very common in developing countries so much so that India is known as the Diabetes Capital of the World. | Advertisement
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