Exercise is the key to make chemotherapy treatment more successful. Generally cancers grow resistant to treatment by generating a web of blood vessels that are so jumbled they fail to provide adequate oxygen to the tumor. Chemotherapy drugs and radiation are designed to seek out well-oxygenated tissue; and with oxygen starvation the tumor gains a sort of cloaking device that protects it from the toxic effects of the therapies. A study led by Duke Cancer Institute (DCI) has revealed that exercise may significantly improve blood flow to tumor sites, thus improving oxygen flow and making treatment with chemotherapy more successful. The research team studied the impact of exercise in models of breast cancer in mice. They randomly assigned a group of mice who exercised, and another group who were sedentary. These mice were then exposed to chemotherapy. Scientists found that exercise stimulated significant improvements in the number and function of blood vessels around the breast tumors, improving oxygen flow to the cancer site. Among the mice that exercised, tumor growth was significantly slower than growth in the sedentary mice, and tumor cell death was 1.5 times higher. The density of small blood vessels was approximately 60% higher in exercised mice compared to the controls, and oxygen transport improved, leading to less oxygen starvation of the cancer tissue. The vasculature in the breast tumors also looked and behaved more normally. "We set about to see whether exercise would affect the tumor perfusion, and could not have guessed that it would be as effective as it was. We were truly amazed by these findings. I have spent the better part of the last 30 years trying to figure out how to eliminate hypoxia in tumors, and have looked at a lot of different approaches- drugs, hyperthermia and metabolic manipulations. None has worked very well, and in some cases, made things worse. So these findings with exercise are quite encouraging," said co-senior author Mark W. Dewhirst, DVM, Ph.D, the Gustavo S. Montana Professor of Radiation Oncology and vice director for Basic Science at DCI. The study is published in the 'Journal of the National Cancer Institute'. Source: Medindia << Britain Introduces Plain Packaging on Cigarette Packets Teens Not Worried About Risks Involved in Exposing Privacy >> Recommended Reading Chemotherapy Drugs Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body. READ MORE Chemotherapy 'Chemo' means medicine or 'drug'; 'therapy' means 'treatment'. Chemotherapy refers to the use of cytotoxic drugs in cancer treatment. READ MORE Garlic Oil May Reduce Adverse Effects of Chemotherapy and Radiotherapy Garlic oil has been found to reduce adverse effects of chemo and radiotherapy in animal study. READ MORE Can Combination Chemotherapy Improve Prognosis of Adrenocortical Cancer? Chemotherapy with the EDP-mitotane regimen appears to have better outcomes in patients with adrenocortical cancer as compared to the streptozocin-mitotane regimen. READ MORE Chronic Lymphocytic Leukemia Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is considered as one of the ‘good cancers’. READ MORE Exercise and Fitness Exercise is about revamping your lifestyle, not just weight loss. Exercise to get healthy – that way, you’ll last longer at it and get better results. READ MORE Hodgkins Lymphoma Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by chemotherapy or by radiotherapy. READ MORE Lifestyle Modification: No Big Deal! Simple and practically possible lifestyle changes can make a huge difference in improving our health status without actually putting much effort. READ MORE Non-Hodgkins Lymphoma Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of subtypes. READ MORE Thalassemia Thalassemia is an inherited blood disorder passed on through parental genes causing the body to produce abnormal hemoglobin. READ MORE Tips to Live Longer Though life is temporary and short, it is possible to maximize the span of our existence by living healthy and savoring every moment of life, read our tips to live longer READ MORE Most Popular on Medindia Noscaphene (Noscapine) Drug Side Effects Calculator Color Blindness Calculator More News on: ThalassemiaChronic Lymphocytic LeukemiaDiet Lifestyle and Heart DiseaseHodgkins LymphomaNon-Hodgkins LymphomaChemotherapyChemotherapy DrugsTips to Live LongerExercise and FitnessLifestyle Modification: No Big Deal!