About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Exercise Improves Blood Flow, Oxygen; Makes Chemotherapy Successful

by Dr. Trupti Shirole on March 20, 2015 at 11:36 AM
Font : A-A+

Exercise Improves Blood Flow, Oxygen; Makes Chemotherapy Successful

Exercise is the key to make chemotherapy treatment more successful. Generally cancers grow resistant to treatment by generating a web of blood vessels that are so jumbled they fail to provide adequate oxygen to the tumor. Chemotherapy drugs and radiation are designed to seek out well-oxygenated tissue; and with oxygen starvation the tumor gains a sort of cloaking device that protects it from the toxic effects of the therapies. A study led by Duke Cancer Institute (DCI) has revealed that exercise may significantly improve blood flow to tumor sites, thus improving oxygen flow and making treatment with chemotherapy more successful.

The research team studied the impact of exercise in models of breast cancer in mice. They randomly assigned a group of mice who exercised, and another group who were sedentary. These mice were then exposed to chemotherapy.

Advertisement

Scientists found that exercise stimulated significant improvements in the number and function of blood vessels around the breast tumors, improving oxygen flow to the cancer site. Among the mice that exercised, tumor growth was significantly slower than growth in the sedentary mice, and tumor cell death was 1.5 times higher. The density of small blood vessels was approximately 60% higher in exercised mice compared to the controls, and oxygen transport improved, leading to less oxygen starvation of the cancer tissue. The vasculature in the breast tumors also looked and behaved more normally.

"We set about to see whether exercise would affect the tumor perfusion, and could not have guessed that it would be as effective as it was. We were truly amazed by these findings. I have spent the better part of the last 30 years trying to figure out how to eliminate hypoxia in tumors, and have looked at a lot of different approaches- drugs, hyperthermia and metabolic manipulations. None has worked very well, and in some cases, made things worse. So these findings with exercise are quite encouraging," said co-senior author Mark W. Dewhirst, DVM, Ph.D, the Gustavo S. Montana Professor of Radiation Oncology and vice director for Basic Science at DCI.

The study is published in the 'Journal of the National Cancer Institute'.

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
First-Ever Successful Pig-To-Human Kidney Transplantation
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Thalassemia Chronic Lymphocytic Leukemia Diet Lifestyle and Heart Disease Hodgkins Lymphoma Non-Hodgkins Lymphoma Chemotherapy Chemotherapy Drugs Tips to Live Longer Exercise and Fitness Lifestyle Modification: No Big Deal! 

Recommended Reading
Chemotherapy Drugs
Chemotherapy drugs perform like 'magic bullets' to destroy cancer cells in the body....
Chemotherapy
'Chemo' means medicine or 'drug'; 'therapy' means 'treatment'. Chemotherapy refers to the use of .....
Garlic Oil May Reduce Adverse Effects of Chemotherapy and Radiotherapy
Garlic oil has been found to reduce adverse effects of chemo and radiotherapy in animal study....
Can Combination Chemotherapy Improve Prognosis of Adrenocortical Cancer?
Chemotherapy with the EDP-mitotane regimen appears to have better outcomes in patients with ......
Chronic Lymphocytic Leukemia
Chronic Lymphocytic Leukemia (CLL) is one of the most common types of adult leukemia and is consider...
Exercise and Fitness
Exercise is about revamping your lifestyle, not just weight loss. Exercise to get healthy – that way...
Hodgkins Lymphoma
Hodgkins lymphoma or Hodgkins disease has the distinction of being the first cancer to be cured by c...
Lifestyle Modification: No Big Deal!
Simple and practically possible lifestyle changes can make a huge difference in improving our health...
Non-Hodgkins Lymphoma
Non Hodgkins Lymphoma is a cancer that affects the lymph tissues. It is made up of a wide array of ....
Thalassemia
Thalassemia is an inherited blood disorder passed on through parental genes causing the body to prod...
Tips to Live Longer
Though life is temporary and short, it is possible to maximize the span of our existence by living h...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use