About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Enzyme Preventing Conversion of Glucose into Fat May Help Treat Diabetes

by Reshma Anand on January 12, 2016 at 3:39 PM
Font : A-A+

Enzyme Preventing Conversion of Glucose into Fat May Help Treat Diabetes

The process of converting glucose in the body involves the formation of a harmful product called "glycerol-3-phosphate." This compound affects organs and fat storage.

Now Canadian researchers have found that a protein known as "glycerol-3-phosphate phosphatase", or G3PP that converts this harmful byproduct of glucose into a non-toxic compound known as glycerol.

Advertisement


While G3PP has been identified in simple creatures including bacteria, algae and yeast, it was not thought to exist in people. But the study found that the enzyme helped metabolize nutrients in the cells of all mammals.

Co-author Marc Prentki said, "Abnormally elevated levels of glucose triggered excessive production of a chemical known as "glycerol-3 phosphate. While this compound plays an essential role in energy production and fat formation, too much of it can overload the insulin-producing cells of the pancreas."
Advertisement

"We found that G3PP is able to break down a great proportion of this excess glycerol phosphate into glycerol and divert it outside the cell, thus protecting the beta cells of the pancreas and various organs from the toxic effects," said Professor Prentki.

The team predicts that this new enzyme will help in developing potential drugs with unique mechanism for obesity, type 2 diabetes and metabolic syndrome.

Dr. Murthy Madiraju, who also worked on the study, said, "By diverting glucose as glycerol, G3PP prevents excessive formation and storage of fat and it also lowers excessive production of glucose in liver, a major problem in diabetes."

Reference: Yves Mugabo, Shangang Zhao, "Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic β-cells and hepatocytes," Proceedings of the National Academy of Sciences, doi: 10.1073/pnas.1514375113

Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
Anemia among Indian Women and Children Remains a Cause of Concern- National Family Health Survey-5
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diabetic Retinopathy Cholesterol Diabetes Diabetic Diet Diabetes - Self-Monitoring of Blood Glucose (SMBG) Insulin Delivery Devices Diabetes and Exercise Diet Lifestyle and Heart Disease Stress Relief Through Alternative Medicine Stress and the Gender Divide 

Most Popular on Medindia

Find a Hospital Daily Calorie Requirements Sanatogen Post-Nasal Drip Turmeric Powder - Health Benefits, Uses & Side Effects Iron Intake Calculator Noscaphene (Noscapine) Blood Pressure Calculator Drug Side Effects Calculator Sinopril (2mg) (Lacidipine)
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Enzyme Preventing Conversion of Glucose into Fat May Help Treat Diabetes Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests