After a year, she stunned doctors at Rochdale Infirmary by conceiving boy-girl twins again.
Last week, newborns, Kian, 5lb 4oz and Ella, 4lb 6.5oz took birth in the hospital through Caesarean section.
"I was ecstatic when I found out we were having twins. I couldn't believe it when it happened again. Catherine has twin sisters, but we weren't expecting this," The Sun quoted Catherine's husband, John, as saying.
"We couldn't ask for anything more than boy and girl twins. It is costing a lot in nappies but we don't mind," he added.