About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Effectiveness of Antimicrobial Drugs to Treat Cholera Examined in Cochrane Review

by Kathy Jones on June 20, 2014 at 7:05 PM
Font : A-A+

 Effectiveness of Antimicrobial Drugs to Treat Cholera Examined in Cochrane Review

An independent review of the effects of treating cholera with antimicrobial drugs was conducted by researchers from the Cochrane Infectious Diseases Group, co-ordinated through the editorial base in LSTM. The results are published in The Cochrane Library.

Cholera is an acute watery diarrhoea caused by infection with the bacterium Vibrio cholerae, which can cause rapid dehydration and death. Effective treatment requires early diagnosis and rehydration using oral rehydration salts or intravenous fluids. This review looked at the effects of adding antimicrobial drugs to this treatment.

Advertisement

Thirty-nine randomized and quasi-randomized controlled clinical trials were included in the review, with a combined total of 4623 participants, both adults and children. Overall the researchers found that antimicrobial therapy shortened the average duration of diarrhoea by about a day and a half when compared to placebo or no treatment. Antimicrobial therapy also reduced the total stool volume by 50% and reduced the amount of rehydration fluids required by 40%, and shortened the duration of fecal extraction of vibrios bacteria by almost three days.

There was substantial variation between trials in the size of these benefits, probably due to differences in the antibiotic used, the trial methods (particularly effective randomization), and the timing of outcome assessment. However the benefits of antibiotics were seen both in trials recruiting only patients with severe dehydration and in those recruiting patients with mixed levels of dehydration.
Advertisement

In direct head-to-head comparisons, researchers found that there were no obvious differences detected in diarrhoea duration or stool volume for tetracycline compared to doxycycline or tetracycline compared to ciprofloxacin or norfloxacin. However, a higher number of studies looked at indirect comparisons and in those cases tetracycline appeared to have larger benefits than doxycycline, norfloxacin and trimethoprim-sulfamethoxazole, while single dose azithromycin shortened the duration of diarrhoea by over a day compared to ciprofloxacin and by half a day compared to erythromycin. Tetracycline was not compared with azithromycin.

Ya'ara Leibovici-Weissman from Tel Aviv University said: "In treating cholera a quick and accurate diagnosis remains key, but it is clear from the results that antimicrobials result in substantial improvements in clinical and microbiological outcomes, with similar effects observed in severely and non-severely ill patients. Our results also point to the likelihood that azithromycin and tetracycline may have some advantages over other antibiotics."



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test Your Knowledge About Chromosomes?
Eating During Sunlight Hours Minimizes Mood Vulnerabilities
Know More About the Digestive System
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Cholera Water Borne Diseases Amoebic Dysentery Drugs Banned in India Food Preservatives - How Safe Are They? 

Most Popular on Medindia

Blood Pressure Calculator Calculate Ideal Weight for Infants Sinopril (2mg) (Lacidipine) Accident and Trauma Care Hearing Loss Calculator How to Reduce School Bag Weight - Simple Tips Selfie Addiction Calculator Turmeric Powder - Health Benefits, Uses & Side Effects Indian Medical Journals A-Z Drug Brands in India
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Effectiveness of Antimicrobial Drugs to Treat Cholera Examined in Cochrane Review Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests