Echocardiographic Screening in General Population Does Not Reduce Risk of Death Due to Heart Attacks

A new study conducted in Norway and published in the journal JAMA Internal Medicine suggests that the risk of death due to myocardial infarction, or heart attack, and stroke was not reduced by echocardiographic screening in the general public for structural and valvular heart disease. Because of the low prevalence of structural heart disease in the general population, echocardiography has traditionally not been considered justified in low-risk individuals, although echocardiography is recommended for screening asymptomatic individuals with a family history of sudden death or hereditary diseases affecting the heart, according to the study background.

Haakon Lindekleiv, M.D., Ph.D., of the University of Tromsø, Norway, and colleagues examined whether echocardiographic screening in the general population improved long-term survival or reduced the risk of cardiovascular disease in a randomized clinical study.

Researchers studied 6,861 middle-aged participants (3,272 in a screening group and 3,589 in a control group). In the screening group, 290 participants (8.9 percent) underwent follow-up examinations because of abnormal findings and cardiac or valvular pathologic conditions were verified in 249 participants (7.6 percent).

"Among the screening group, the prevalence of structural heart and valvular disease was 7.6 percent, and the most common finding was valvular disease. However, diagnosing asymptomatic disease is useful only if it can lead to clinical action that slows or stops progression of disease. Although sclerosis of the aortic and mitral valves has been associated with a substantial increased risk of cardiovascular disease, we did not find that early diagnosis of valvular disease in the general population translated into reduced risk of death or cardiovascular events," the study notes.

During 15 years of follow-up, 880 people (26.9 percent) in the screening group died and 989 people (27.6 percent) in the control group died. No significant differences were found in the measures for sudden death, mortality from heart disease, or incidence of fatal or nonfatal myocardial infarction and stroke, according to the results.

'This supports existing guidelines that echocardiography is not recommended for cardiovascular risk assessment in asymptomatic adults," the study concludes. "Although our results were negative, we believe that they are of clinical importance because they may contribute to reducing the overuse of echocardiography."

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Commentary: Echoing the Appropriate Use Criteria

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In a related commentary, Erin D. Michos, M.D., M.H.S., and Theodore P. Abraham, M.D., of the Johns Hopkins University School of Medicine, Baltimore, write: "In the critical evaluation of any screening test, one must answer the following questions: whether the test detects a disease process early, whether appropriate intervention is available for the disease detected that is more effective if applied earlier than later, whether the test improves outcomes in the population screened (as well as the number needed to screen to find preclinical disease), and whether patients are harmed by the screening test."

"Given the low prevalence of structural heart disease in the general population, the number needed to screen is high, and the findings of the Tromsø Study suggest that early intervention for preclinical disease did not improve outcomes. Furthermore there may be potential for harm. Although echocardiography is nonradiating [does not involve exposure to radiation], a normal resting echocardiogram does not exclude coronary disease," they conclude.

Editor's Note: Please see the article for additional information, including other authors, author contributions and affiliations, financial disclosures, funding and support, etc.



Source-Eurekalert