Drugs Acting Through New Protein Increase Body's HDL Levels

by Ramya Rachamanti on January 21, 2019 at 3:06 PM

Drugs Acting Through New Protein Increase Body's HDL Levels
ORP2 is a new protein which is responsible for transporting cholesterol inside cells that opens the way for new drugs to increase the body's good cholesterol levels, according to the Sydney researchers.

ORP2 can increase the amount of cholesterol in cells, a process called cholesterol efflux. We think this pathway will be very important for the development of a drug to increase this good cholesterol, said Rob Yang, Professor from the University of New South Wales in Australia.

Until now, drugs including statins have targeted bad cholesterol (LDL) by inhibiting its synthesis in the liver in an effort to mitigate the risk of heart disease and stroke.

However, while statins are effective at lowering LDL levels, they do little to increase the levels of good cholesterol (HDL) and there is no other drug in use that can significantly boost the human body's HDL levels.

Up to 90 per cent of a cell's cholesterol is found at the cell's plasma membrane, said the study published in the journal Molecular Cell.

"Knowing the molecules that deliver cholesterol to the plasma membrane itself is a huge step forward. The transport of cholesterol to the plasma membrane is the key to the generation of HDL.

If such a drug could be developed, it would not replace statins, but would be used complementarily, with one drug used to reduce the bad cholesterol and the other to increase levels of the good, Yang suggested.

Importantly, ORP2 could also be targeted to fight cancer.

The rampant and uncontrolled growth of cells that characterises cancer could be stopped in its tracks by reducing the amount of cholesterol produced.

ORP2 could offer a new strategic line of research and possibly succeed where the use of statins in this area hasn't, Yang noted.

Source: IANS

News A-Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
High Cholesterol Drug Toxicity Diet Lifestyle and Heart Disease Drugs Banned in India Natural Remedies for Cholesterol – How Effective Are They? Magical Millets for Your Health Lipid Profile Screening Baby Food - Basics Diet and Nutrition Tips for Athletes Nutrition IQ 

Recommended Reading
Dyslipidemia is a condition due to imbalance of fats in blood. Find out more about dyslipidemia, ......
Baby Food - Basics
The healthiest baby foods can be made at home. Products from big brands that claim to develop infant...
Diet and Nutrition Tips for Athletes
Athletes can be physically fit by consuming a well balanced nutritious diet, which keeps them mental...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Drugs Banned in India
Several drugs are either banned or withdrawn after introduction in the market....
High Cholesterol
High cholesterol level in blood are a risk for heart disease and stroke. They get deposited in the w...
Lipid Profile Screening
Lipid profile test/screening is done by measuring total cholesterol, HDL-cholesterol and LDL – chole...
Magical Millets for Your Health
Millets are far more nutrient dense than wheat and rice. They are inexpensive and tasty too. Nutriti...
Natural Remedies for Cholesterol – How Effective Are They?
Certain natural remedies are effective in controlling high cholesterol, when aided by lifestyle chan...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use