According to research about 10.6% of the inherited genetic risk for developing coronary artery disease (CAD) can be explained by specific DNA variations. This research was reported today at the American Society of Human Genetics 2012 meeting.
The research, conducted by scientists in the CARDIoGRAMplusC4D consortium, pinpointed 20 previously unidentified mutations during a two-stage meta-analysis of 63,746 patients with CAD, which causes more deaths worldwide than any other disease.
These genetic variants generally were infrequently found in the DNA of the 130,681 individuals without heart disease who were in the control group.
The new mutations have boosted to 47 the total number of DNA variants that have thus far been linked to an increased risk for developing CAD, said Panos Deloukas, Ph.D., who co-led the study and heads the Genetics of Complex Traits in Humans research group at the Wellcome Trust Sanger Institute, Cambridge, UK.
Scientists had previously estimated that 30 to 60% of the variation in CAD might be attributable to genetic risk factors, according to a study published in 2005*. The research reported at ASHG 2012 expands the number of specific genes that are likely involved.
"We no longer assume that coronary heart disease is triggered by just a handful of genes, each with a strong effect on a person's risk for the disease," said Dr. Deloukas. "Our research supports the current assumption that heart disease risk is determined by a large group of genes, each with a modest effect on risk."
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Many of the newly identified variations are in genes that operate in biological pathways involved in the body's metabolism of lipids or fats as well as in inflammation.
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"Exactly how inflammation plays a role in heart attack remains a topic of ongoing research," said Dr. Deloukas, adding that the consortium's findings underscore the roles of high cholesterol levels and inflammation in CAD.
Source-Eurekalert