Discovery of Brain’s Cognitive Control Mechanism Helps in Interventions for Dementia

How does your brain lets you to imagine and think about a particular goal? A team of researchers have tried answering how the brain determines which direction to let its thoughts fly. By using structural imaging techniques to convert brain scans into "wiring diagrams" of connections between brain regions, the researchers at the University of Pennsylvania, University of California and United States Army Research Laboratory used the structure of these neural networks to reveal the fundamental rules that govern which parts of the brain are most able to exert "cognitive control" over thoughts and actions.

This study is the first to provide a mechanistic explanation for how the frontal cortex accomplishes this feat, exerting control over trillions of individual neurons. The work weds cutting-edge neuroscience with the emerging field of network science, which is often used to study social systems.

It applies control theory, a field traditionally used to study electrical and mechanical systems, to show that being on the "outskirts" of the brain is necessary for the frontal cortex to dynamically control the direction of thoughts and goal-directed behavior.

This fundamental understanding of how the brain controls its activity could help lead to better interventions for medical conditions associated with reduced cognitive control, such as autism, schizophrenia or dementia.

Senior author Danielle Bassett said that the results suggest that the human brain resembles a flock of birds. The flock comes to a consensus about which way to fly based on how close the birds are to one another and in what formation.

Birds that fly at specific places in the flock can drive changes in the flock's direction, being leaders in a so-called multi-agent system. Similarly, particular regions of your brain are predisposed to control your thoughts based on where they lie in relation to other regions. The study is published in Nature Communications.

Source-ANI