COPD: New Diagnostic Criteria Proposed

by Colleen Fleiss on  November 14, 2019 at 12:06 AM Respiratory Disease News
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New criteria for diagnosing chronic obstructive pulmonary disease (COPD) have been published by researchers at National Jewish Health. COPD is the fourth leading cause of death in the United States.
COPD: New Diagnostic Criteria Proposed
COPD: New Diagnostic Criteria Proposed

The proposal, published in Chronic Obstructive Pulmonary Diseases: Journal of the COPD Foundation, expands diagnostic criteria from a single measure of lung function to include environmental exposure, symptoms, and abnormal CT scans. If used, the new diagnostic criteria could increase the number of patients diagnosed with COPD, by 15 percent to 36 percent, or about 2 million to 5 million people.

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"Our proposed diagnostic criteria better capture the full spectrum of people suffering from COPD," said James Crapo, MD, senior author on the paper. "This can lead to better care for patients and stimulate research to slow or stop progression of the disease or even prevent it." COPD is a progressive, complex combination of airway inflammatory disease, chronic bronchitis and emphysema. Smoking tobacco is the most common cause of COPD, although about 15 percent of COPD patients never smoked. Approximately 12 million people in the United States have been diagnosed with COPD, and many million more are thought to have undiagnosed COPD. Every year, about 120,000 people in the United States die of the COPD.

The researchers evaluated 8,784 smokers and former smokers enrolled in the COPDGene® study. At enrollment, the researchers documented patients' environmental exposures (smoking), symptoms (shortness of breath, chronic cough and phlegm), structural abnormalities on CT scans (emphysema, gas-trapping and airway wall thickness) and lung function or spirometry (total volume of air exhaled from the lungs, and the volume of air exhaled in one second). They then correlated those measures with mortality and loss of lung function five years later and compared them with smokers with none of the other criteria.

All patients met one of the criteria: smoking history. Those meeting either one, two or three additional criteria all had increased risks of losing significant lung function in five years or dying.

Smokers meeting one of the other three criteria were designated as having Possible COPD. Their risk of losing significant lung function was 26 percent greater than smokers meeting no additional criteria, and a 28 percent higher chance of dying within five years.

Those with all four diagnostic criteria were designated as having Definite COPD. They had a 188 percent greater chance of losing significant lung function over five years and more than 5 times the risk of dying.

"If we diagnose COPD based only on impaired lung function, then we miss many patients in the early stages of the disease," said Dr. Crapo, who is also co-principal investigator of COPDGene®. "While some physicians do empirically treat patients with symptoms, many patients are not getting therapy that can improve their symptoms, their quality of life, and might extend their lives.

"Right now people who do not meet the current diagnostic criteria for COPD are not included in clinical trials of experimental COPD therapies. Our proposed diagnostic criteria could open clinical trials to these people, stimulate important research of potential therapies to slow, stop or even prevent progression of the disease."

Source: Eurekalert

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