People who are sensitive to anxiety or negative thinking, or who are impulsive or sensation-seeking are known to be at greater risk of substance abuse.

The study involved working with 1,038 high-risk British students and their teachers at 21 secondary schools in London. People who are sensitive to anxiety or negative thinking, or who are impulsive or sensation-seeking are known to be at greater risk of substance abuse.
"There were signs that the program delayed onset and reduced frequency of cannabis use in all youth who participated in the interventions, but the results also consistently showed that the program was particularly effective in preventing cannabis use among those most at risk of using sensation seekers," senior author Patricia Conrod from University of Montreal.
Approximately 25 percent of high-risk youth took up cannabis use over the course of this two-year trial. The intervention was associated with a 33 percent reduction in cannabis use rates within the first six months after the intervention and then reduced frequency of use another six months later.
The findings appeared in the journal Addiction.
Source-Medindia