Cigarette Smoke Makes Antibiotic-Resistant Superbugs Deadlier

by Bidita Debnath on April 4, 2015 at 5:01 PM
Font : A-A+

Cigarette Smoke Makes Antibiotic-Resistant Superbugs Deadlier

A new study conducted at University of California demonstrated that an antibiotic-resistant superbug called Methicillin-resistant Staphylococcus aureus (MRSA) can be more aggressive and dangerous due to cigarette smoke.

The study suggested that the drug can cause life-threatening skin, bloodstream and surgical site infections or pneumonia and it can be worse if it comes in contact with cigarette smoke.


Dr. Laura E. Crotty Alexander, senior author and assistant clinical professor of medicine at UC San Diego, asserted that they already knew that smoking cigarettes harms human respiratory and immune cells, and now they had shown that, on the flipside, smoke could also stress out invasive bacteria and make them more aggressive.

Crotty Alexander and her team infected macrophages, immune cells that engulf pathogens, with MRSA. Some of the bacteria were grown normally and some were grown with cigarette smoke extract and they found that while the macrophages were equally able to take up the two bacterial populations, they had a harder time killing the MRSA that had been exposed to cigarette smoke extract.

Alexander's team tested the bacteria's susceptibility to individual mechanisms macrophages typically employ to kill bacteria. Once inside macrophages, smoke-exposed MRSA were more resistant to killing by reactive oxygen species, the chemical burst that macrophages use to destroy their microbial meals.

The team also discovered that smoke-exposed MRSA were more resistant to killing by antimicrobial peptides, small protein pieces the immune system uses to poke holes in bacterial cells and trigger inflammation and the effect was dose-dependent, meaning that the more smoke extract they used, the more resistant the MRSA became.

Alexander said that cigarette smokers were known to be more susceptible to infectious diseases and now they had the evidence that cigarette smoke-induced resistance in MRSA may be an additional contributing factor.

Source: ANI

News A-Z
News Category
What's New on Medindia
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Health Hazards of Smoking Smoking And Cancer Smoking And Tobacco Diet Lifestyle and Heart Disease Smoking among Women Cigarette Smoking - A Silent Killer Antioxidants to Help You When You Quit Smoking 

Recommended Reading
New Ad by Centres for Disease Control Targets E-cigarette Users in the US
In a statement, the CDC said that smokers must give up tobacco completely to fully protect their ......
Health Experts Defend Sale of E-Cigarettes In Abu Dhabi
Dismissing widespread concerns that the devices could lure adolescents into nicotine addiction, ......
Smoking Water Pipes Cause More Damage Than Cigarettes
Policy-makers, health advocates and experts have warned that one hour of smoking from hookahs ...
Britain Introduces Plain Packaging on Cigarette Packets
Britain is all set to be the first European Union nation to introduce plain packaging on cigarette ....
Antioxidants to Help You When You Quit Smoking
Smoking is injurious to health, but it sure is a tough addiction to stop. Cure yourself with the pow...
Cigarette Smoking - A Silent Killer
Smoking kills the smoker silently, pushing him towards serious illnesses, which slowly lead to ......
Health Hazards of Smoking
Smoking causes many diseases and affects the overall health of smokers....
Smoking among Women
Tobacco use in women is on the rise. The health risks of tobacco are far too many has never done a w...
Smoking And Cancer
Smoking is the most important preventable cause of cancer in the world....
Smoking And Tobacco
Encyclopedia section of medindia briefs you about the History of Tobacco...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use