About Careers MedBlog Contact us

Cigarette Smoke Makes Antibiotic-Resistant Superbugs Deadlier

by Bidita Debnath on April 4, 2015 at 5:01 PM
Font : A-A+

Cigarette Smoke Makes Antibiotic-Resistant Superbugs Deadlier

A new study conducted at University of California demonstrated that an antibiotic-resistant superbug called Methicillin-resistant Staphylococcus aureus (MRSA) can be more aggressive and dangerous due to cigarette smoke.

The study suggested that the drug can cause life-threatening skin, bloodstream and surgical site infections or pneumonia and it can be worse if it comes in contact with cigarette smoke.


Dr. Laura E. Crotty Alexander, senior author and assistant clinical professor of medicine at UC San Diego, asserted that they already knew that smoking cigarettes harms human respiratory and immune cells, and now they had shown that, on the flipside, smoke could also stress out invasive bacteria and make them more aggressive.

Crotty Alexander and her team infected macrophages, immune cells that engulf pathogens, with MRSA. Some of the bacteria were grown normally and some were grown with cigarette smoke extract and they found that while the macrophages were equally able to take up the two bacterial populations, they had a harder time killing the MRSA that had been exposed to cigarette smoke extract.

Alexander's team tested the bacteria's susceptibility to individual mechanisms macrophages typically employ to kill bacteria. Once inside macrophages, smoke-exposed MRSA were more resistant to killing by reactive oxygen species, the chemical burst that macrophages use to destroy their microbial meals.

The team also discovered that smoke-exposed MRSA were more resistant to killing by antimicrobial peptides, small protein pieces the immune system uses to poke holes in bacterial cells and trigger inflammation and the effect was dose-dependent, meaning that the more smoke extract they used, the more resistant the MRSA became.

Alexander said that cigarette smokers were known to be more susceptible to infectious diseases and now they had the evidence that cigarette smoke-induced resistance in MRSA may be an additional contributing factor.

Source: ANI


Recommended Reading

Latest Research News

 Microparticle Therapy Offers a Glimmer of Cure for Multiple Sclerosis
Utilizing microparticles for therapy could mark a significant milestone in the fight against multiple sclerosis (MS) and other autoimmune diseases.
 Cranial Epilepsy Surgery Offers Hope for Children With Drug-Resistant Epilepsy
A study revealed that children with drug-resistant epilepsy (DRE) had the highest survival rate beyond 10 years when they underwent cranial epilepsy surgery.
Shaping the Brain's Destiny for Treating Neuropsychiatric Disorders
From childhood through adolescence, the brain constantly changes, and researchers are making strides in identifying a potential treatment target for neuropsychiatric disorders.
Uncovering the Reasons Behind Japan's Fertility Rate Drop
In Japan, babies born in 2022 was also a record low at 770,747, down 40,875 from 2021, revealed data.
Why Is Deep Brain Stimulation Important for Memory?
The first direct evidence supported the main theory for how human memory is amalgamated during sleep.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Cigarette Smoke Makes Antibiotic-Resistant Superbugs Deadlier Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests