About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Certain Prostate Cancer Drugs Can Spur Cancer Cells to Grow

by Hannah Punitha on August 24, 2008 at 3:13 PM
Font : A-A+

 Certain Prostate Cancer Drugs Can Spur Cancer Cells to Grow

Researchers from the University of Rochester Medical Centre have found that certain prostate cancer drugs can spur some cancer cells to grow.

Hormone therapy, a common treatment for men with advanced prostate cancer, generally keeps the cancer at bay for a year or two, but later fails in patients whose disease has spread.

Advertisement

The team led by Chawnshang Chang, Ph.D., director of the George Whipple Laboratory for Cancer Research at the University of Rochester Medical Center showed that androgen receptor, through which male hormones like testosterone work under certain conditions spurs growth, and at other times inhibits growth- just like the same molecule does to hair in different locations on a man's head.

The researchers said that these findings raise the possibility that under some conditions, certain treatments designed to treat prostate cancer could instead remove one of the body's natural brakes on the spread of the disease in the body.
Advertisement

The research in the laboratory involved tracking the disease in mice and also analysing human prostate cancer cells in culture.

"When a man receives hormone therapy, initially the treatment works well, and his PSA (prostate specific antigen) level goes down," said Edward Messing, M.D., a urologist and an author of the paper.

"But inevitably, the PSA will start climbing again, and that is usually the first sign that the treatment is beginning to fail. It's a sign that the cancer in the prostate is making a comeback," he added.

The research team found that blocking the receptor indeed prevents some cells in the prostate from growing, but unexpectedly blocking the receptor can actually spurs other prostate cells to grow.

The androgen receptor in prostate support cells known as stromal cells stimulates growth of cells. After turning off the molecule in stromal cells, growth of cancer cells in the prostate slowed down.

"The effects of the androgen receptor on hair growth in men vary dramatically depending on where in the body the receptor is working," said Chang.

"When the receptor is very active in the mustache area, more hair grows. When it's very active on the top of the skull, toward the front, hair falls out and men become bald. And the hair on the back of the head is insensitive to the receptor. The effects of hormones depend on the location.

"We found that the same is true within the cells of the prostate itself," he added.



Source: ANI
SPH
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
Long-Term Glycemic Control - A Better Measure of COVID-19 Severity
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Drug Toxicity Prostate Cancer Cancer and Homeopathy Parkinsons Disease Surgical Treatment Trans-Urethral Resection of the Prostate Colorectal Cancer Signature Drug Toxicity Prostate Cancer Facts Cancer Facts Cancer 

Recommended Reading
Prostate Biopsy
Encyclopedia section of medindia gives general information about prostate gland...
Prostate Enlargement due to Benign Hyperplasia of Prostate or BPH - Animation
Are you troubled by urinary symptoms of prostate enlargement - View this medindia animation to ......
Prostate Cancer - Animation
Interactive section of Medindia gives details regarding Prostate Cancer...
Colorectal Cancer
Colorectal cancer is a cancer that starts in the colon or the rectum. Colorectal cancer is the third...
Drug Toxicity
Drug toxicity is an adverse reaction of the body towards a drug that results as a side effect of a d...
Prostate Cancer
This cancer affects men over the age of 50 years and screening with rectal examination and PSA can h...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use