Around 20,000 lung or colon cancer patients will take part in the Cancer Diagnosis Decision rules (CANDID) study that will be funded by the National Institute for Health Research School for Primary Care Research (NIHR SPCR) with researchers hoping to determine the symptoms that are more predictive of lung or colon cancer.
Genetic testing will be carried out after the recruitment phase of the study to establish how much extra information genetics provides over and above the clinical information.
The two million-pound five-year study is the largest award made by the NIHR SPCR and aims to improve the referral process patients go through before being diagnosed. Currently GPs must refer urgent cases within two weeks and for other cases, up to 62 days for referral; however it has been reported that some patients have to wait much longer and some have visited their GP more than once before being referred.
The study will use patient samples from the eight centres within the NIHR National School for Primary Research: Southampton, Oxford, Bristol, Birmingham, Nottingham, University College London, Manchester and Keele.
The NIHR SPCR Director, Professor Richard Hobbs adds: 'The NIHR School for Primary Care Research is pleased to be supporting this ambitious new study, the funding for which was made possible after we had redesigned the way that the School funds its research to enable larger, collaborative, longer term research to compete with short term single centre studies.
"The UK presently spends only around 5 per cent of its overall health research budgets on prevention and for many diseases, and cancer in particular, the earlier it is recognised and diagnosed, the better the prognosis or outcomes. This is why CANDID is important for patients and the NHS. Pleasingly, this major prospective research also builds on earlier research into symptoms that may predict cancer based on retrospective data, some of which was also supported by the NIHR SPCR."