About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Breathe-in or Ingestible Antibody can Help Prevent Allergy, Asthma

by Julia Samuel on January 29, 2018 at 11:06 AM
Font : A-A+

Breathe-in or Ingestible Antibody can Help Prevent Allergy, Asthma

A new ingestible or inhalable antibody that can prevent allergic reactions and asthma in adults, could pave way for a far more effective allergy medicine.

The antibody has a unique mechanism through which it blocks the immune effect that causes the allergic reactions.

Advertisement


"We can now describe the interaction of this antibody with its target and the conformational changes very accurately. This allows us to understand, how it interferes with the IgE and its specific receptors on the immune cells of the body, which are responsible for releasing histamine in an allergic reaction," said Edzard Spillner, Associate Professor at the Aarhus University.

When exposed to external allergens, an allergic person produces high levels of IgE molecules.

The function of the antibody is that it interferes with binding of IgE to the two specific effector (CD23 and FceRI) on the immune cells, thereby making it impossible for the allergy molecule to bind.
Advertisement

Furthermore, the scientists have observed that the antibody also removes the IgE molecules even after binding to its receptors.

"Once the IgE on immune cells can be eliminated, it doesn't matter that the body produces millions of allergen-specific IgE molecules. When we can remove the trigger, the allergic reaction and symptoms will not occur," Spillner said.

In the laboratory, it took only 15 minutes to disrupt the interaction between the allergy molecules and the immune cells.

The research team has conducted ex vivo experiments with blood cells from patients allergic to birch pollen and insect venom. However, the method can be transferred to virtually all other allergies and asthma, they said.

Because of its chemical structure, the new antibody might be inhaled or swallowed, and these new consumption methods will make easy, cheap and much and more comfortable for the patients to handle.

"It is a so-called single domain antibody which easily produced in processes using only microorganisms. It is also extremely stable, and this provides new opportunities for how the antibody can be administered to patients," Spillner said.



Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Childhood Asthma Asthma Amoebic Dysentery Remedies for Seasonal Allergy Relief Allergy - Symptom Evaluation Wheezing Churg-Strauss Syndrome Tests for Asthma Stay Well This Winter 

Recommended Reading
Asthma
It's a lung condition characterized by inflammation of the bronchi and constriction of the airways ....
Allergy - Symptom Evaluation
An allergic reaction may be mild or severe. It usually involves the skin, respiratory system, ......
Dealing with Pollen Allergy
The plants around you that give you sniffles in your nose at specific time of the year are the ......
Multiple Drug Allergy Syndrome
Multiple drug allergy syndrome or multiple drug hypersensitivity syndrome is a condition that ......
Amoebic Dysentery
Amoebic dysentery or amoebiasis is an infection of the intestine that causes diarrhoea most frequent...
Childhood Asthma
Childhood asthma is a condition that affects airways in children and interferes with their daily act...
Churg-Strauss Syndrome
Churg-Strauss Syndrome is a rare disease characterized by inflammation of blood vessels that can res...
Remedies for Seasonal Allergy Relief
Understanding the cause and mechanism of seasonal allergy can help in choosing the right treatment. ...
Stay Well This Winter
Winter is associated with staying huddled indoors, people scurrying home to escape the piercing wint...
Tests for Asthma
Do you find it difficult to breathe especially during the cold weather? You may need to get tested f...
Wheezing
Wheezing is a sound arising from the airways due to an obstruction or narrowing, which prevents the ...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use