About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Breakthrough: Scientists Grow Hybrid Embryos Containing Both Human and Sheep Cells

by Colleen Fleiss on February 20, 2018 at 1:24 AM
Font : A-A+

Breakthrough: Scientists Grow Hybrid Embryos Containing Both Human and Sheep Cells

Scientists have transferred human stem cells into sheep embryos, an advance that may pave the way for growing transplant organs inside animals.

The new finding paves way for genetically tailoring the organs to be compatible with the immune system of the patient receiving them, thus removing the possibility of rejection, the report said.

Advertisement


Using stem cell and genomic editing technologies, human stem cells were successfully transferred into early sheep embryos, producing embryos for which about one in every 100,000 cells were human.

These chimeras -- a term adopted from Greek mythology -- were only allowed to develop for 28 days, the researchers said while presenting the results at the American Association for the Advancement of Science in Texas.
Advertisement

The experiment began with Hiro Nakauchi, from the University of Tokyo, who grew a mouse with a rat pancreas and a rat with a mouse pancreas.

When cells from the rat-grown mouse pancreas were transplanted into a diabetic mouse, they made enough insulin to cure the condition without being rejected.

Mice and rats are different types of rodents with the former having thin slightly hairy tails, while rats have thicker hairless scaly tails.

"The next step was to move into large animals," Nakauchi said. Since this was prohibited in Japan, he moved to the Stanford University in the US.

Nakauchi's rodent work has demonstrated that you can "grow organs in a different species and cure a disease without [suppressing the immune system]," added co-researcher Pablo Ross, Professor at from the University of California, Davis.

"We are working together to translate the technology into humans, to solve the terrible shortage of organs for transplantation. In the US, 20 people die every day because they cannot get the organs they need," Ross explained.

The novel approach helps to produce animal embryos that are genetically incapable of growing a particular organ.

Then the embryos are injected with human stem cells. The overall proportion of human cells in the chimeric embryo may be small but, as it develops in the womb, the human cells fill the gap and produce the missing organ that the animal's own genes cannot create, the report said.

If the technology is able to grow human organs inside other species, organ transplants can become a possibility beyond critical conditions.

While it may take many years to develop chimeric transplant technology to the stage where it could be used safely on patient, "things are moving fast," Ross said.

Source: IANS
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
E-cigarettes Use Linked to Erectile Dysfunction
Memory Loss - Can it be Recovered?
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Surgical Treatment 

Recommended Reading
Transplantation
Organ and tissue transplantation can give a second chance at life to thousands of people. Learn ......
Kidney Transplantation
Since the early times, the novel idea of transplanting tissues and other body parts from one ......
Chimera Viruses may Help Fight Against Lymphomas
Chimera virus that allows the study of molecules to treat cancers caused by human herpes virus ......
Regeneration of Pig's Pancreas Proves Successful, Say Scientists
Researchers from Japan have succeeded in growing the pancreas in genetically modified pigs by ......

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use